TY - GEN
T1 - Liver elasticity and viscosity quantification using Shearwave Dispersion Ultrasound Vibrometry (SDUV)
AU - Chen, Shigao
AU - Urban, Matthew W.
AU - Pislaru, Cristina
AU - Kinnick, Randall
AU - Greenleaf, James F.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Noninvasive quantification of liver elasticity is a promising alternative to liver biopsy to stage liver fibrosis, a condition afflicting hundreds of millions of patients worldwide. Quantitative measurement of elasticity (in unit of Pascal) is required in this application because liver fibrosis is a diffuse disease where abnormality is not confined to a local region and there is no normal background tissue to provide contrast. SDUV uses an ultrasound "push" beam to stimulate formation of propagating harmonic shear waves in the studied tissue. The propagation speed of induced shear waves is frequency dependent (dispersive) and relates to the tissue's mechanical properties. Shear wave speeds at multiple frequencies (typically hundreds of Hertz) are measured by a separate ultrasound "detect" beam in pulse echo mode and fit with a theoretical dispersion model to inversely solve for tissue elasticity and viscosity. A special pulse sequence has been developed to facilitate a single ultrasound array transducer for both push and detect function, which makes SDUV compatible with current ultrasound scanners. Feasibility of this pulse sequence is demonstrated by in vivo SDUV measurements in porcine liver using a dual transducer prototype.
AB - Noninvasive quantification of liver elasticity is a promising alternative to liver biopsy to stage liver fibrosis, a condition afflicting hundreds of millions of patients worldwide. Quantitative measurement of elasticity (in unit of Pascal) is required in this application because liver fibrosis is a diffuse disease where abnormality is not confined to a local region and there is no normal background tissue to provide contrast. SDUV uses an ultrasound "push" beam to stimulate formation of propagating harmonic shear waves in the studied tissue. The propagation speed of induced shear waves is frequency dependent (dispersive) and relates to the tissue's mechanical properties. Shear wave speeds at multiple frequencies (typically hundreds of Hertz) are measured by a separate ultrasound "detect" beam in pulse echo mode and fit with a theoretical dispersion model to inversely solve for tissue elasticity and viscosity. A special pulse sequence has been developed to facilitate a single ultrasound array transducer for both push and detect function, which makes SDUV compatible with current ultrasound scanners. Feasibility of this pulse sequence is demonstrated by in vivo SDUV measurements in porcine liver using a dual transducer prototype.
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U2 - 10.1109/IEMBS.2009.5334992
DO - 10.1109/IEMBS.2009.5334992
M3 - Conference contribution
C2 - 19965159
AN - SCOPUS:77950979054
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 2252
EP - 2255
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -