Liver aquaporins: significance in canalicular and ductal bile formation.

Raúl A. Marinelli, Sergio A. Gradilone, Flavia I. Carreras, Giuseppe Calamita, Guillermo L. Lehmann

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.

Original languageEnglish (US)
Pages (from-to)130-136
Number of pages7
JournalAnnals of hepatology : official journal of the Mexican Association of Hepatology
Volume3
Issue number4
StatePublished - 2004
Externally publishedYes

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Aquaporins
Bile
Liver
Hepatocytes
Intrahepatic Bile Ducts
Water
Ion Channels
Membrane Proteins
Membranes

Cite this

Marinelli, R. A., Gradilone, S. A., Carreras, F. I., Calamita, G., & Lehmann, G. L. (2004). Liver aquaporins: significance in canalicular and ductal bile formation. Annals of hepatology : official journal of the Mexican Association of Hepatology, 3(4), 130-136.

Liver aquaporins : significance in canalicular and ductal bile formation. / Marinelli, Raúl A.; Gradilone, Sergio A.; Carreras, Flavia I.; Calamita, Giuseppe; Lehmann, Guillermo L.

In: Annals of hepatology : official journal of the Mexican Association of Hepatology, Vol. 3, No. 4, 2004, p. 130-136.

Research output: Contribution to journalArticle

Marinelli, RA, Gradilone, SA, Carreras, FI, Calamita, G & Lehmann, GL 2004, 'Liver aquaporins: significance in canalicular and ductal bile formation.', Annals of hepatology : official journal of the Mexican Association of Hepatology, vol. 3, no. 4, pp. 130-136.
Marinelli, Raúl A. ; Gradilone, Sergio A. ; Carreras, Flavia I. ; Calamita, Giuseppe ; Lehmann, Guillermo L. / Liver aquaporins : significance in canalicular and ductal bile formation. In: Annals of hepatology : official journal of the Mexican Association of Hepatology. 2004 ; Vol. 3, No. 4. pp. 130-136.
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