TY - JOUR
T1 - Liver aquaporins
T2 - significance in canalicular and ductal bile formation.
AU - Marinelli, Raúl A.
AU - Gradilone, Sergio A.
AU - Carreras, Flavia I.
AU - Calamita, Giuseppe
AU - Lehmann, Guillermo L.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2004
Y1 - 2004
N2 - Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.
AB - Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.
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U2 - 10.1016/s1665-2681(19)32090-3
DO - 10.1016/s1665-2681(19)32090-3
M3 - Review article
C2 - 15657554
AN - SCOPUS:13844309817
SN - 1665-2681
VL - 3
SP - 130
EP - 136
JO - Annals of hepatology : official journal of the Mexican Association of Hepatology
JF - Annals of hepatology : official journal of the Mexican Association of Hepatology
IS - 4
ER -