Liver and kidney transplantation for polycystic disease

D. Rohan Jeyarajah, Thomas A. Gonwa, Giuliano Testa, Osman Abbasoglu, Robert Goldstein, Bo S. Husberg, Marlon F. Levy, Goran B. Klintmalm

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Background. With the poor results of resective and fenestration procedures for polycystic liver disease (PCLD), we present the first series of patients receiving orthotopic liver transplantation for this condition. Methods. Five of our six patients with PCLD had polycystic kidney disease also. Three of these five received combined organ transplants, while the other two required subsequent kidney transplants. Results. Forty-eight and 52 months after orthotopic liver transplantation, all surviving patients had relief of their pain, distention, and anorexia. Two patients had succumbed to infectious complications and died at 15 and 24 months after transplant. Conclusions. We conclude that patients with PCLD can be transplanted safely for the relief of their distention and anorexia, with good results. Those patients with both PCLD and polycystic kidney disease who are not dialysis dependent can be managed for several years with isolated liver transplantation and then receive kidney transplantation if needed. Those who are dialysis dependent should receive combined liver-kidney transplantation. Unfortunately, patients with polycystic disease seem to be very susceptible to infectious complications after organ transplantation.

Original languageEnglish (US)
Pages (from-to)529-532
Number of pages4
JournalTransplantation
Volume66
Issue number4
DOIs
StatePublished - Aug 27 1998

ASJC Scopus subject areas

  • Transplantation

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    Jeyarajah, D. R., Gonwa, T. A., Testa, G., Abbasoglu, O., Goldstein, R., Husberg, B. S., Levy, M. F., & Klintmalm, G. B. (1998). Liver and kidney transplantation for polycystic disease. Transplantation, 66(4), 529-532. https://doi.org/10.1097/00007890-199808270-00019