Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients

Lack of association with affective illness

E. Richelson, K. Snyder, J. Carlson, M. Johnson, Stephen T Turner, A. Lumry, E. Boerwinkle, C. F. Sing

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r=-.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.

Original languageEnglish (US)
Pages (from-to)457-462
Number of pages6
JournalAmerican Journal of Psychiatry
Volume143
Issue number4
StatePublished - 1986

Fingerprint

Ion Transport
Blood Donors
Lithium
Erythrocytes
Sodium
Ions
Population
In Vitro Techniques

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients : Lack of association with affective illness. / Richelson, E.; Snyder, K.; Carlson, J.; Johnson, M.; Turner, Stephen T; Lumry, A.; Boerwinkle, E.; Sing, C. F.

In: American Journal of Psychiatry, Vol. 143, No. 4, 1986, p. 457-462.

Research output: Contribution to journalArticle

Richelson, E, Snyder, K, Carlson, J, Johnson, M, Turner, ST, Lumry, A, Boerwinkle, E & Sing, CF 1986, 'Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: Lack of association with affective illness', American Journal of Psychiatry, vol. 143, no. 4, pp. 457-462.
Richelson, E. ; Snyder, K. ; Carlson, J. ; Johnson, M. ; Turner, Stephen T ; Lumry, A. ; Boerwinkle, E. ; Sing, C. F. / Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients : Lack of association with affective illness. In: American Journal of Psychiatry. 1986 ; Vol. 143, No. 4. pp. 457-462.
@article{4b8a9bd123364da0af45774fd91e3d97,
title = "Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: Lack of association with affective illness",
abstract = "The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r=-.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.",
author = "E. Richelson and K. Snyder and J. Carlson and M. Johnson and Turner, {Stephen T} and A. Lumry and E. Boerwinkle and Sing, {C. F.}",
year = "1986",
language = "English (US)",
volume = "143",
pages = "457--462",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "4",

}

TY - JOUR

T1 - Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients

T2 - Lack of association with affective illness

AU - Richelson, E.

AU - Snyder, K.

AU - Carlson, J.

AU - Johnson, M.

AU - Turner, Stephen T

AU - Lumry, A.

AU - Boerwinkle, E.

AU - Sing, C. F.

PY - 1986

Y1 - 1986

N2 - The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r=-.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.

AB - The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r=-.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.

UR - http://www.scopus.com/inward/record.url?scp=0022586833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022586833&partnerID=8YFLogxK

M3 - Article

VL - 143

SP - 457

EP - 462

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 4

ER -