Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: Lack of association with affective illness

E. Richelson, K. Snyder, J. Carlson, M. Johnson, S. Turner, A. Lumry, E. Boerwinkle, C. F. Sing

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r=-.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.

Original languageEnglish (US)
Pages (from-to)457-462
Number of pages6
JournalAmerican Journal of Psychiatry
Volume143
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Psychiatry and Mental health

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