Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: A biochemical study

Elliott Richelson

doi:10.1126/science.860126

Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: A biochemical study

Elliott Richelson

Neuroscience

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked by tetrodotoxin. These data provide biochemical evidence that lithium ions enter by way of the sodium channel which may be a major pathway for entry of this ion into electrically active cells.

Original language	English (US)
Pages (from-to)	1001-1002
Number of pages	2
Journal	Science
Volume	196
Issue number	4293
DOIs	https://doi.org/10.1126/science.860126
State	Published - 1977

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title = "Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: A biochemical study",

abstract = "Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked by tetrodotoxin. These data provide biochemical evidence that lithium ions enter by way of the sodium channel which may be a major pathway for entry of this ion into electrically active cells.",

author = "Elliott Richelson",

year = "1977",

doi = "10.1126/science.860126",

language = "English (US)",

volume = "196",

pages = "1001--1002",

journal = "Science",

issn = "0036-8075",

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number = "4293",

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T1 - Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells

T2 - A biochemical study

AU - Richelson, Elliott

PY - 1977

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N2 - Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked by tetrodotoxin. These data provide biochemical evidence that lithium ions enter by way of the sodium channel which may be a major pathway for entry of this ion into electrically active cells.

AB - Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked by tetrodotoxin. These data provide biochemical evidence that lithium ions enter by way of the sodium channel which may be a major pathway for entry of this ion into electrically active cells.

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U2 - 10.1126/science.860126

DO - 10.1126/science.860126

M3 - Article

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AN - SCOPUS:0017405267

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SP - 1001

EP - 1002

JO - Science

JF - Science

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ER -

Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: A biochemical study

Abstract

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