Liquid biopsy in gastrointestinal cancers

Aman Saini, Yash Pershad, Hassan Albadawi, Malia Kuo, Sadeer Alzubaidi, Sailendra Naidu, M. Grace Knuttinen, Rahmi Oklu

Research output: Contribution to journalReview articlepeer-review


Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.

Original languageEnglish (US)
Article number75
Issue number4
StatePublished - Dec 1 2018


  • Circulating tumor DNA
  • Circulating tumor cells
  • Gastrointestinal cancer
  • Liquid biopsy

ASJC Scopus subject areas

  • Clinical Biochemistry


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