Liquid biopsy in gastrointestinal cancers

Aman Saini; Yash Pershad; Hassan Albadawi; Malia Kuo; Sadeer Alzubaidi; Sailendra Naidu; M. Grace Knuttinen; Rahmi Oklu

doi:10.3390/diagnostics8040075

Liquid biopsy in gastrointestinal cancers

Aman Saini, Yash Pershad, Hassan Albadawi, Malia Kuo, Sadeer Alzubaidi, Sailendra Naidu, M. Grace Knuttinen, Rahmi Oklu

Diagnostic Radiology

Research output: Contribution to journal › Review article › peer-review

Abstract

Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.

Original language	English (US)
Article number	75
Journal	Diagnostics
Volume	8
Issue number	4
DOIs	https://doi.org/10.3390/diagnostics8040075
State	Published - Dec 1 2018

Keywords

Circulating tumor DNA
Circulating tumor cells
Gastrointestinal cancer
Liquid biopsy

ASJC Scopus subject areas

Clinical Biochemistry

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10.3390/diagnostics8040075

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title = "Liquid biopsy in gastrointestinal cancers",

abstract = "Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.",

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AU - Saini, Aman

AU - Pershad, Yash

AU - Albadawi, Hassan

AU - Kuo, Malia

AU - Alzubaidi, Sadeer

AU - Naidu, Sailendra

AU - Knuttinen, M. Grace

AU - Oklu, Rahmi

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.

AB - Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.

KW - Circulating tumor DNA

KW - Circulating tumor cells

KW - Gastrointestinal cancer

KW - Liquid biopsy

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Liquid biopsy in gastrointestinal cancers

Abstract

Keywords

ASJC Scopus subject areas

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