Liquid biopsy for diffuse intrinsic pontine glioma: An update

Victor M. Lu, Erica A. Power, Liang Zhang, David J. Daniels

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Diffuse intrinsic pontine glioma (DIPG), otherwise known as diffuse midline glioma with H3K27M mutation, is a devastating brainstem glioma without a cure. Efforts are currently underway to better optimize molecular diagnoses through biological sampling, which today remains largely limited to surgical biopsy sampling. Surgical intervention is not without its risks, and therefore a preference remains for a less invasive modality that can provide biological information about the tumor. There is emerging evidence to suggest that a liquid biopsy, targeting biofluids such as CSF and blood plasma, presents an attractive alternative for brain tumors in general. In this update, the authors provide a summary of the progress made to date regarding the use of liquid biopsy to diagnose and monitor DIPG, and they also propose future development and applications of this technique moving forward, given its unique histone biology.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalJournal of Neurosurgery: Pediatrics
Volume24
Issue number5
DOIs
StatePublished - Jan 1 2019

Keywords

  • Biomarkers
  • Diffuse intrinsic pontine glioma
  • DIPG
  • Epigenetic
  • H3K27M
  • Liquid biopsy
  • Oncology

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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