TY - JOUR
T1 - Liposuction
T2 - A less invasive surgical method of debulking plexiform neurofibromas
AU - Babovic, Srdan
AU - Bite, Uldis
AU - Karnes, Pamela S.
AU - Babovic-Vuksanovic, Dusica
PY - 2003/7/1
Y1 - 2003/7/1
N2 - BACKGROUND. Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder in humans. The hallmark of NF1 is development of neural tumors. Plexiform neurofibromas are a major source of morbidity associated with NF1. Surgical removal of these particular tumors is associated with a high risk of damage of surrounding vital structures as well as a risk of significant hemorrhage. Surgical debulking of tumors also sometimes leads to extensive scarring, which may be very disfiguring. OBJECTIVE AND METHODS. We report a novel approach to the surgical therapy of plexiform neurofibromas using liposuction in two patients. RESULTS. Debulking of plexiform neurofibromas with liposuction was successful in both patients. Postoperative follow-up 6 months later showed no evidence of tumor regrowth in either case. CONCLUSION. Liposuction may be a preferable surgical method for debulking of superficial plexiform neurofibromas in patients with NF1. This method is less invasive than conventional surgical tumor debulking.
AB - BACKGROUND. Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder in humans. The hallmark of NF1 is development of neural tumors. Plexiform neurofibromas are a major source of morbidity associated with NF1. Surgical removal of these particular tumors is associated with a high risk of damage of surrounding vital structures as well as a risk of significant hemorrhage. Surgical debulking of tumors also sometimes leads to extensive scarring, which may be very disfiguring. OBJECTIVE AND METHODS. We report a novel approach to the surgical therapy of plexiform neurofibromas using liposuction in two patients. RESULTS. Debulking of plexiform neurofibromas with liposuction was successful in both patients. Postoperative follow-up 6 months later showed no evidence of tumor regrowth in either case. CONCLUSION. Liposuction may be a preferable surgical method for debulking of superficial plexiform neurofibromas in patients with NF1. This method is less invasive than conventional surgical tumor debulking.
UR - http://www.scopus.com/inward/record.url?scp=0037478580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037478580&partnerID=8YFLogxK
U2 - 10.1046/j.1524-4725.2003.29199.x
DO - 10.1046/j.1524-4725.2003.29199.x
M3 - Article
C2 - 12828709
AN - SCOPUS:0037478580
SN - 1076-0512
VL - 29
SP - 785
EP - 787
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 7
ER -