Lipoprotein(a) and accelerated coronary artery disease in cardiac transplant recipients

M. Barbir, S. Kushwaha, B. Hunt, A. Macken, M. Yacoub, G. Thompson, D. Robinson, Andrew Mitchell

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

High concentrations of serum lipoprotein(a) (Lp(a)) are associated with an increased risk of atherosclerotic vascular disease in the non-transplanted population. However its relation with accelerated coronary artery disease (CAD) in cardiac transplant recipients has not been reported. We measured serum Lp(a) in 130 cardiac transplant recipients undergoing routine follow-up, which included annual coronary angiography. The median Lp(a) concentration in 33 patients with CAD was 71 mg/dl, which was significantly higher than the corresponding value of 22 mg/dL in the 97 patients without CAD (p= 0·0006). Multivariant analysis showed the serum Lp(a) value to be a higher significant risk factor for CAD irrespective of the other factors included in the regression analysis. Thus a high concentration of serum Lp(a) is an important, independent risk factor for the development of accelerated CAD in transplant recipients.

Original languageEnglish (US)
Pages (from-to)1500-1502
Number of pages3
JournalThe Lancet
Volume340
Issue number8834-8835
DOIs
StatePublished - Dec 26 1992

ASJC Scopus subject areas

  • Medicine(all)

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