Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

Maria Paz Marzolo, Guojun Bu

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

Amyloid-β (Aβ) peptide accumulation in the brain is central to the pathogenesis of Alzheimer's disease (AD). Aβ is produced through proteolytic processing of a transmembrane protein, β-amyloid precursor protein (APP), by β- and γ-secretases. Mounting evidence has demonstrated that alterations in APP cellular trafficking and localization directly impact its processing to Aβ. Members of the low-density lipoprotein receptor family, including LRP, LRP1B, SorLA/LR11, and apoER2, interact with APP and regulate its endocytic trafficking. Additionally, APP trafficking and processing are greatly affected by cellular cholesterol content. In this review, we summarize the current understanding of the roles of lipoprotein receptors and cholesterol in APP trafficking and processing and their implication for AD pathogenesis and therapy.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume20
Issue number2
DOIs
StatePublished - Apr 2009

Keywords

  • Alzheimer's disease
  • Amyloid precursor protein
  • Amyloid-β peptide
  • Cholesterol
  • Lipoprotein receptors

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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