Lipoprotein lipase and triglyceride-rich lipoprotein metabolism

John M. Miles, Yongsoon Park, William S. Harris

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lipoprotein lipase (LPL) is the key enzyme responsible for fat storage. It hydrolyzes triglyceride contained in circulating very low-density lipoproteins and chylomicrons; the fatty acids that are produced are transported locally into tissues, whereas glycerol is released into the circulation. Abnormalities in LPL activity have been described in a variety of hypertriglyceridemic states, including diabetes mellitus, and in some situations may contribute to atherosclerosis. Previous in vivo studies suggest that LPL is saturable, with maximum rates of fatty acid transport and storage occurring at plasma triglyceride concentrations in the 300 to 400 mg/dL range. At higher triglyceride concentrations, significant nonen-zymatic uptake, primarily by the reticuloendothelial system, can occur. Impaired neutrophil, platelet, and pulmonary function have been described in association with IV infusion of lipid emulsions at high rates. There is no evidence that lipid emulsions produce any of these adverse effects at plasma triglyceride concentrations below 300 to 400 mg/dL. Inordinate hypertriglyceridemia can usually be avoided by limiting lipid infusion rates to 30 to 50 mg/kg-h, a rate sufficient to meet nutritional needs under most conditions.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalNutrition in Clinical Practice
Volume16
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Lipoprotein Lipase
Lipoproteins
Triglycerides
Emulsions
Fatty Acids
Lipids
Chylomicrons
Mononuclear Phagocyte System
VLDL Lipoproteins
Hypertriglyceridemia
Glycerol
Atherosclerosis
Diabetes Mellitus
Neutrophils
Blood Platelets
Fats
Lung
lipoprotein triglyceride
Enzymes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Miles, J. M., Park, Y., & Harris, W. S. (2001). Lipoprotein lipase and triglyceride-rich lipoprotein metabolism. Nutrition in Clinical Practice, 16(5), 273-279.

Lipoprotein lipase and triglyceride-rich lipoprotein metabolism. / Miles, John M.; Park, Yongsoon; Harris, William S.

In: Nutrition in Clinical Practice, Vol. 16, No. 5, 2001, p. 273-279.

Research output: Contribution to journalArticle

Miles, JM, Park, Y & Harris, WS 2001, 'Lipoprotein lipase and triglyceride-rich lipoprotein metabolism', Nutrition in Clinical Practice, vol. 16, no. 5, pp. 273-279.
Miles, John M. ; Park, Yongsoon ; Harris, William S. / Lipoprotein lipase and triglyceride-rich lipoprotein metabolism. In: Nutrition in Clinical Practice. 2001 ; Vol. 16, No. 5. pp. 273-279.
@article{5b44dcf5d0054a078c4960b641fdd0ec,
title = "Lipoprotein lipase and triglyceride-rich lipoprotein metabolism",
abstract = "Lipoprotein lipase (LPL) is the key enzyme responsible for fat storage. It hydrolyzes triglyceride contained in circulating very low-density lipoproteins and chylomicrons; the fatty acids that are produced are transported locally into tissues, whereas glycerol is released into the circulation. Abnormalities in LPL activity have been described in a variety of hypertriglyceridemic states, including diabetes mellitus, and in some situations may contribute to atherosclerosis. Previous in vivo studies suggest that LPL is saturable, with maximum rates of fatty acid transport and storage occurring at plasma triglyceride concentrations in the 300 to 400 mg/dL range. At higher triglyceride concentrations, significant nonen-zymatic uptake, primarily by the reticuloendothelial system, can occur. Impaired neutrophil, platelet, and pulmonary function have been described in association with IV infusion of lipid emulsions at high rates. There is no evidence that lipid emulsions produce any of these adverse effects at plasma triglyceride concentrations below 300 to 400 mg/dL. Inordinate hypertriglyceridemia can usually be avoided by limiting lipid infusion rates to 30 to 50 mg/kg-h, a rate sufficient to meet nutritional needs under most conditions.",
author = "Miles, {John M.} and Yongsoon Park and Harris, {William S.}",
year = "2001",
language = "English (US)",
volume = "16",
pages = "273--279",
journal = "Nutrition in Clinical Practice",
issn = "0884-5336",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Lipoprotein lipase and triglyceride-rich lipoprotein metabolism

AU - Miles, John M.

AU - Park, Yongsoon

AU - Harris, William S.

PY - 2001

Y1 - 2001

N2 - Lipoprotein lipase (LPL) is the key enzyme responsible for fat storage. It hydrolyzes triglyceride contained in circulating very low-density lipoproteins and chylomicrons; the fatty acids that are produced are transported locally into tissues, whereas glycerol is released into the circulation. Abnormalities in LPL activity have been described in a variety of hypertriglyceridemic states, including diabetes mellitus, and in some situations may contribute to atherosclerosis. Previous in vivo studies suggest that LPL is saturable, with maximum rates of fatty acid transport and storage occurring at plasma triglyceride concentrations in the 300 to 400 mg/dL range. At higher triglyceride concentrations, significant nonen-zymatic uptake, primarily by the reticuloendothelial system, can occur. Impaired neutrophil, platelet, and pulmonary function have been described in association with IV infusion of lipid emulsions at high rates. There is no evidence that lipid emulsions produce any of these adverse effects at plasma triglyceride concentrations below 300 to 400 mg/dL. Inordinate hypertriglyceridemia can usually be avoided by limiting lipid infusion rates to 30 to 50 mg/kg-h, a rate sufficient to meet nutritional needs under most conditions.

AB - Lipoprotein lipase (LPL) is the key enzyme responsible for fat storage. It hydrolyzes triglyceride contained in circulating very low-density lipoproteins and chylomicrons; the fatty acids that are produced are transported locally into tissues, whereas glycerol is released into the circulation. Abnormalities in LPL activity have been described in a variety of hypertriglyceridemic states, including diabetes mellitus, and in some situations may contribute to atherosclerosis. Previous in vivo studies suggest that LPL is saturable, with maximum rates of fatty acid transport and storage occurring at plasma triglyceride concentrations in the 300 to 400 mg/dL range. At higher triglyceride concentrations, significant nonen-zymatic uptake, primarily by the reticuloendothelial system, can occur. Impaired neutrophil, platelet, and pulmonary function have been described in association with IV infusion of lipid emulsions at high rates. There is no evidence that lipid emulsions produce any of these adverse effects at plasma triglyceride concentrations below 300 to 400 mg/dL. Inordinate hypertriglyceridemia can usually be avoided by limiting lipid infusion rates to 30 to 50 mg/kg-h, a rate sufficient to meet nutritional needs under most conditions.

UR - http://www.scopus.com/inward/record.url?scp=0344858071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344858071&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0344858071

VL - 16

SP - 273

EP - 279

JO - Nutrition in Clinical Practice

JF - Nutrition in Clinical Practice

SN - 0884-5336

IS - 5

ER -