Lipoprotein-associated phospholipase A2: Review of its role as a marker and a potential participant in coronary endothelial dysfunction

Shahar Lavi, Ronit Lavi, Joseph P. McConnell, Lilach O. Lerman, Amir Lerman

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The role of inflammation in atherosclerosis continues to emerge. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel plasma biomarker, circulates in the blood bound mainly to low-density lipoprotein (LDL) and promotes vascular inflammation. Several epidemiological studies have shown that circulating levels of Lp-PLA2 are an independent risk factor for cardiovascular events. Recent studies demonstrate that Lp-PLA2 is also associated with endothelial dysfunction and early atherosclerosis. This review provides an overview of these studies, suggests plausible mechanisms for the association between endothelial dysfunction and Lp-PLA2, and highlights future potential therapies.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalMolecular Diagnosis and Therapy
Volume11
Issue number4
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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