Lipolytic responsiveness to epinephrine in nondiabetic and diabetic humans

G. D. Divertie, M. D. Jensen, P. E. Cryer, J. M. Miles

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

To determine whether the sensitivity of adipose tissue lipolysis to catecholamines is increased in poorly controlled insulin-dependent diabetes, the lipolytic response to epinephrine was measured in seven nondiabetic volunteers and seven poorly controlled diabetic subjects with use of [1- 14C]palmitate as a tracer. Subjects received sequential 1-h infusions of epinephrine, which produced epinephrine concentrations of ~1,000, ~1,750, ~3,500, and ~6,000 pmol/l. A pancreatic clamp was used to maintain constant plasma hormone levels. Concentration-response curves were constructed for each subject from the integrated lipolytic response during each epinephrine infusion. There was no difference in maximal lipolytic response (117 ± 19 vs. 152 ± 11 μmol · kg-1 · h-1) or in maximally effective (3,171 ± 267 vs. 3,357 ± 349 pmol/l) or half-maximally effective (1,081 ± 109 vs. 1,015 ± 120 pmol/l) epinephrine concentrations between nondiabetic and diabetic subjects, respectively (all P = NS). In control subjects, maximum β-hydroxybutyrate concentrations were achieved at lower epinephrine concentrations than those required for a maximum lipolytic effect. Thus, under pancreatic clamp conditions, the lipolytic response to epinephrine in nondiabetic and diabetic subjects was similar.

Original languageEnglish (US)
Pages (from-to)E1130-E1135
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume272
Issue number6 35-6
DOIs
StatePublished - Jun 1997

Keywords

  • Free fatty acids
  • Insulin-dependent diabetes mellitus
  • Kinetics
  • Lipolysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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