Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy

M. Nagamatsu, K. K. Nickander, J. D. Schmelzer, A. Raya, D. A. Wittrock, H. Tritschler, Phillip Anson Low

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - To determine whether lipoic acid (LA) will reduce oxidative stress in diabetic peripheral nerves and improve neuropathy. RESEARCH DESIGN AND METHODS - We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats. LA, in doses of 20, 50, and 100 mg/kg, was administered intraperitoneally five times per week after onset of diabetes. RESULTS - NBF in SDN was reduced by 50%; LA did not affect the NBF of normal nerves but improved that of SDN in a dose-dependent manner. After 1 month of treatment, LA-supplemented rats (100 mg/kg) exhibited normal NBF. The most sensitive and reliable indicator of oxidative stress was a reduction in reduced glutathione, which was significantly reduced in streptozotocin- induced diabetic and α-tocopherol-deficient nerves; it was improved in a dose-dependent manner in LA-supplemented rats. The conduction velocity of the digital nerve was reduced in SDN and was significantly improved by LA. CONCLUSIONS - These studies suggest that LA improves SDN, in significant part by reducing the effects of oxidative stress. The drug may have potential in the treatment of human diabetic neuropathy.

Original languageEnglish (US)
Pages (from-to)1160-1167
Number of pages8
JournalDiabetes Care
Volume18
Issue number8
StatePublished - 1995

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Thioctic Acid
Diabetic Neuropathies
Neural Conduction
Streptozocin
Oxidative Stress
Peripheral Nerves
Tocopherols
Electrophysiology
Glutathione
Research Design

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Nagamatsu, M., Nickander, K. K., Schmelzer, J. D., Raya, A., Wittrock, D. A., Tritschler, H., & Low, P. A. (1995). Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care, 18(8), 1160-1167.

Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. / Nagamatsu, M.; Nickander, K. K.; Schmelzer, J. D.; Raya, A.; Wittrock, D. A.; Tritschler, H.; Low, Phillip Anson.

In: Diabetes Care, Vol. 18, No. 8, 1995, p. 1160-1167.

Research output: Contribution to journalArticle

Nagamatsu, M, Nickander, KK, Schmelzer, JD, Raya, A, Wittrock, DA, Tritschler, H & Low, PA 1995, 'Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy', Diabetes Care, vol. 18, no. 8, pp. 1160-1167.
Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18(8):1160-1167.
Nagamatsu, M. ; Nickander, K. K. ; Schmelzer, J. D. ; Raya, A. ; Wittrock, D. A. ; Tritschler, H. ; Low, Phillip Anson. / Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. In: Diabetes Care. 1995 ; Vol. 18, No. 8. pp. 1160-1167.
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AB - OBJECTIVE - To determine whether lipoic acid (LA) will reduce oxidative stress in diabetic peripheral nerves and improve neuropathy. RESEARCH DESIGN AND METHODS - We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats. LA, in doses of 20, 50, and 100 mg/kg, was administered intraperitoneally five times per week after onset of diabetes. RESULTS - NBF in SDN was reduced by 50%; LA did not affect the NBF of normal nerves but improved that of SDN in a dose-dependent manner. After 1 month of treatment, LA-supplemented rats (100 mg/kg) exhibited normal NBF. The most sensitive and reliable indicator of oxidative stress was a reduction in reduced glutathione, which was significantly reduced in streptozotocin- induced diabetic and α-tocopherol-deficient nerves; it was improved in a dose-dependent manner in LA-supplemented rats. The conduction velocity of the digital nerve was reduced in SDN and was significantly improved by LA. CONCLUSIONS - These studies suggest that LA improves SDN, in significant part by reducing the effects of oxidative stress. The drug may have potential in the treatment of human diabetic neuropathy.

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