Abstract
Lipidosis is a term, now infrequently used, that describes families of genetic disorders characterized by the storage of excess lipid molecules in neurons and other nervous system and somatic cells, proportionate to the normal distribution of these compounds. The most severe forms of almost all of these diseases manifest progressive neurodegeneration, with or without somatic, cutaneous, or ocular findings that allow the differential diagnosis to be narrowed. Hematopoietic stem cell transplantation, enzyme replacement, and enzyme enhancement therapy are all treatment options available or under investigation for these diseases.
Original language | English (US) |
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Title of host publication | Encyclopedia of the Neurological Sciences |
Publisher | Elsevier Inc. |
Pages | 901-902 |
Number of pages | 2 |
ISBN (Electronic) | 9780123851574 |
ISBN (Print) | 9780123851581 |
DOIs | |
State | Published - Jan 1 2014 |
Keywords
- Adrenoleukodystrophy
- Fabry
- Krabbe
- Leukodystrophy
- Lipidosis
- Lysosomal storage
- Metachromatic leukodystrophy
- Niemann-Pick
- Peroxisomal disease
- Sandhoff
- Tay-Sachs
ASJC Scopus subject areas
- General Medicine