Abstract
Background Prior work suggests that adult bipolar disorder (BD) is associated with increased oxidative stress and inflammation. This exploratory study examined markers of lipid and protein oxidation and inflammation in adolescents with and at varying risk for BD type I (BD-I). Methods Blood was obtained from four groups of adolescents (9-20 years of age): (1) healthy comparison subjects with no personal or family history of psychiatric disorders (n=13), (2) subjects with no psychiatric diagnosis and at least one parent with BD-I ('high-risk', n=15), (3) subjects with at least one parent with BD-I and a diagnosis of depressive disorder not-otherwise-specified ('ultra-high-risk', n=20), and (4) first-episode patients exhibiting mixed or manic symptoms that received a diagnosis of BD-I (n=16). Plasma levels of lipid peroxidation (LPH, 4-HNE, 8-ISO), protein carbonyl, and inflammation (IL-1α-β, IL-6, IL-10, IFNγ, TNFα) were assessed using analysis of variance and covariance models. Results LPH was lower in adolescents with fully syndromal BD than controls, while LPH levels in the at-risk groups were between healthy controls and fully syndromal BD. Post-hoc analysis showed a non-significant increase in the (4-HNE+8-ISO)/LPH ratio suggesting a potential conversion of LPH into late-stage markers of lipid peroxidation. There were no significant differences among protein carbonyl content and inflammatory markers. Conclusions In adolescents, fully syndromal BD is associated with significant reductions in LPH levels, and LPH levels decrease along the spectrum of risk for BD-I. Quantifying lipid peroxidation in longitudinal studies may help clarify the role of LPH in BD risk progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 176-183 |
| Number of pages | 8 |
| Journal | Journal of Affective Disorders |
| Volume | 192 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- Adolescent bipolar disorder
- At-risk adolescents
- Lipid peroxidation
- Oxidative stress markers
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder. / Scola, Gustavo; McNamara, Robert K.; Croarkin, Paul E; Leffler, Jarrod M.; Cullen, Kathryn R.; Geske, Jennifer R.; Biernacka, Joanna M; Frye, Mark A; Delbello, Melissa P.; Andreazza, Ana C.
In: Journal of Affective Disorders, Vol. 192, 01.03.2016, p. 176-183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder
AU - Scola, Gustavo
AU - McNamara, Robert K.
AU - Croarkin, Paul E
AU - Leffler, Jarrod M.
AU - Cullen, Kathryn R.
AU - Geske, Jennifer R.
AU - Biernacka, Joanna M
AU - Frye, Mark A
AU - Delbello, Melissa P.
AU - Andreazza, Ana C.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background Prior work suggests that adult bipolar disorder (BD) is associated with increased oxidative stress and inflammation. This exploratory study examined markers of lipid and protein oxidation and inflammation in adolescents with and at varying risk for BD type I (BD-I). Methods Blood was obtained from four groups of adolescents (9-20 years of age): (1) healthy comparison subjects with no personal or family history of psychiatric disorders (n=13), (2) subjects with no psychiatric diagnosis and at least one parent with BD-I ('high-risk', n=15), (3) subjects with at least one parent with BD-I and a diagnosis of depressive disorder not-otherwise-specified ('ultra-high-risk', n=20), and (4) first-episode patients exhibiting mixed or manic symptoms that received a diagnosis of BD-I (n=16). Plasma levels of lipid peroxidation (LPH, 4-HNE, 8-ISO), protein carbonyl, and inflammation (IL-1α-β, IL-6, IL-10, IFNγ, TNFα) were assessed using analysis of variance and covariance models. Results LPH was lower in adolescents with fully syndromal BD than controls, while LPH levels in the at-risk groups were between healthy controls and fully syndromal BD. Post-hoc analysis showed a non-significant increase in the (4-HNE+8-ISO)/LPH ratio suggesting a potential conversion of LPH into late-stage markers of lipid peroxidation. There were no significant differences among protein carbonyl content and inflammatory markers. Conclusions In adolescents, fully syndromal BD is associated with significant reductions in LPH levels, and LPH levels decrease along the spectrum of risk for BD-I. Quantifying lipid peroxidation in longitudinal studies may help clarify the role of LPH in BD risk progression.
AB - Background Prior work suggests that adult bipolar disorder (BD) is associated with increased oxidative stress and inflammation. This exploratory study examined markers of lipid and protein oxidation and inflammation in adolescents with and at varying risk for BD type I (BD-I). Methods Blood was obtained from four groups of adolescents (9-20 years of age): (1) healthy comparison subjects with no personal or family history of psychiatric disorders (n=13), (2) subjects with no psychiatric diagnosis and at least one parent with BD-I ('high-risk', n=15), (3) subjects with at least one parent with BD-I and a diagnosis of depressive disorder not-otherwise-specified ('ultra-high-risk', n=20), and (4) first-episode patients exhibiting mixed or manic symptoms that received a diagnosis of BD-I (n=16). Plasma levels of lipid peroxidation (LPH, 4-HNE, 8-ISO), protein carbonyl, and inflammation (IL-1α-β, IL-6, IL-10, IFNγ, TNFα) were assessed using analysis of variance and covariance models. Results LPH was lower in adolescents with fully syndromal BD than controls, while LPH levels in the at-risk groups were between healthy controls and fully syndromal BD. Post-hoc analysis showed a non-significant increase in the (4-HNE+8-ISO)/LPH ratio suggesting a potential conversion of LPH into late-stage markers of lipid peroxidation. There were no significant differences among protein carbonyl content and inflammatory markers. Conclusions In adolescents, fully syndromal BD is associated with significant reductions in LPH levels, and LPH levels decrease along the spectrum of risk for BD-I. Quantifying lipid peroxidation in longitudinal studies may help clarify the role of LPH in BD risk progression.
KW - Adolescent bipolar disorder
KW - At-risk adolescents
KW - Lipid peroxidation
KW - Oxidative stress markers
UR - http://www.scopus.com/inward/record.url?scp=84955451561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955451561&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2015.12.020
DO - 10.1016/j.jad.2015.12.020
M3 - Article
C2 - 26735329
AN - SCOPUS:84955451561
VL - 192
SP - 176
EP - 183
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -