Lipid abnormalities of xanthomatous nerves

J. K. Yao, Peter J Dyck, K. P. Cannon, J. Ludwig

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The lipid composition of nerves, with and without xanthomatous alteration, and other tissues, was investigated post-mortem in a 36-year-old man with cholestatic hepatitis of unknown cause and insulin-dependent diabetes mellitus (IDDM). Cholesteryl esters were found to be markedly increased in both endoneurium and epi- and perineurium of hepatic nerves (showing xanthomatous change), but not in sciatic nerve (without this change). Cholesteryl ester concentrations were also increased, but to a lesser degree, in kidney tissue. The fatty acid composition of stored cholesteryl ester in hepatic nerve endoneurium revealed that oleic acid was the most favoured substrate for esterification. A widespread depletion of triacylglycerol was also demonstrated in hepatic and sciatic nerves and liver and skin tissues obtained from this patient. This abnormality did not appear to be due to an alcoholic or biliary cirrhosis, or to inanition. Whether the depletion of triacylglycerol is drug-related or represents an endogenous metabolic error remains unclear.

Original languageEnglish (US)
Pages (from-to)597-603
Number of pages7
JournalBrain
Volume107
Issue number2
StatePublished - 1984

Fingerprint

Lipids
Nerve
Peripheral Nerves
peripheral nerves
Cholesterol Esters
Esters
nerve tissue
cholesteryl esters
Tissue
Liver
Sciatic Nerve
lipids
liver
Depletion
Triglycerides
Oleic acid
Insulin
Esterification
Medical problems
Chemical analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Yao, J. K., Dyck, P. J., Cannon, K. P., & Ludwig, J. (1984). Lipid abnormalities of xanthomatous nerves. Brain, 107(2), 597-603.

Lipid abnormalities of xanthomatous nerves. / Yao, J. K.; Dyck, Peter J; Cannon, K. P.; Ludwig, J.

In: Brain, Vol. 107, No. 2, 1984, p. 597-603.

Research output: Contribution to journalArticle

Yao, JK, Dyck, PJ, Cannon, KP & Ludwig, J 1984, 'Lipid abnormalities of xanthomatous nerves', Brain, vol. 107, no. 2, pp. 597-603.
Yao JK, Dyck PJ, Cannon KP, Ludwig J. Lipid abnormalities of xanthomatous nerves. Brain. 1984;107(2):597-603.
Yao, J. K. ; Dyck, Peter J ; Cannon, K. P. ; Ludwig, J. / Lipid abnormalities of xanthomatous nerves. In: Brain. 1984 ; Vol. 107, No. 2. pp. 597-603.
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