Lipid abnormalities in hereditary neuropathy. Part 1. Serum non-polar lipids

Jeffrey K. Yao, Ralph D. Ellefson, Peter J Dyck

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The non-polar lipids from sera of 54 patients, with various types of hereditary motor and sensory neuropathies, and from 72 healthy subjects were evaluated. A small but highly significant decrease in the percentage of linoleate to total fatty acids in both cholesteryl ester and triglyceride fractions was found in the sera of the neuropathy patients, except in those who had dominantly inherited sensory neuropathy (HSN-I) and who had spinocerebellar degeneration with retinitis pigmentosa and other features (SpC+). A significant decrease of serum lecithin-cholesterol acyltransferase activity was also found in those patients with hereditary motor and sensory neuropathies, Type I and Type II (two types of peroneal muscular atrophy). The biochemical basis of these abnormalities is not apparent. The biochemical abnormalities reported here have been found in several neurologic disorders and hence are unlikely to be disease-specific.

Original languageEnglish (US)
Pages (from-to)161-175
Number of pages15
JournalJournal of the Neurological Sciences
Volume29
Issue number2-4
DOIs
StatePublished - 1976

Fingerprint

Charcot-Marie-Tooth Disease
Lipids
Serum
Hereditary Sensory and Motor Neuropathy
Spinocerebellar Degenerations
Phosphatidylcholine-Sterol O-Acyltransferase
Retinitis Pigmentosa
Cholesterol Esters
Linoleic Acid
Nervous System Diseases
Healthy Volunteers
Triglycerides
Fatty Acids

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Lipid abnormalities in hereditary neuropathy. Part 1. Serum non-polar lipids. / Yao, Jeffrey K.; Ellefson, Ralph D.; Dyck, Peter J.

In: Journal of the Neurological Sciences, Vol. 29, No. 2-4, 1976, p. 161-175.

Research output: Contribution to journalArticle

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