Lipid abnormalities and renal disease: Is dyslipidemia a predictor of progression of renal disease?

Errol D. Crook, Anantha Thallapureddy, Stephen Migdal, John M. Flack, Eddie L. Greene, Abdullah Salahudeen, John K. Tucker, Herman A. Taylor

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Dyslipidemia is a cardiovascular disease (CVD) risk factor that is associated with enhanced atherosclerosis and plaque instability. Renal insufficiency is associated with abnormalities in lipoprotein metabolism in both the early and the advanced stages of chronic renal failure. These include alterations in apolipoprotein A (apo A)- and B- containing lipoproteins, high-density lipoproteins, and triglycerides. In animal models, these alterations in lipid metabolism and action lead to macrophage activation and infiltration in the kidney with resultant tubulointerstitial and endothelial cell injury. Limited data in humans suggest that, in addition to contributing to CVD, dyslipidemia may be a risk factor for the progression of renal disease. The effects of dyslipidemia on the kidney are mainly observed in those with other risk factors for renal disease progression such as hypertension, diabetes, and proteinuria. Renal disease is a strong risk factor for CVD and African Americans have high rates of renal disease. Therefore, examining the effects of dyslipidemia on the development or progression or renal disease will be an important question for the Jackson Heart Study and is the topic of this review.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalAmerican Journal of the Medical Sciences
Volume325
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Chronic kidney disease
  • Dyslipidemia
  • HDL cholesterol
  • Jackson Heart Study
  • LDL cholesterol
  • Triglycerides

ASJC Scopus subject areas

  • Medicine(all)

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    Crook, E. D., Thallapureddy, A., Migdal, S., Flack, J. M., Greene, E. L., Salahudeen, A., Tucker, J. K., & Taylor, H. A. (2003). Lipid abnormalities and renal disease: Is dyslipidemia a predictor of progression of renal disease? American Journal of the Medical Sciences, 325(6), 340-348. https://doi.org/10.1097/00000441-200306000-00005