Linking long-term dietary patterns with gut microbial enterotypes

Gary D. Wu; Jun Chen; Christian Hoffmann; Kyle Bittinger; Ying Yu Chen; Sue A. Keilbaugh; Meenakshi Bewtra; Dan Knights; William A. Walters; Rob Knight; Rohini Sinha; Erin Gilroy; Kernika Gupta; Robert Baldassano; Lisa Nessel; Hongzhe Li; Frederic D. Bushman; James D. Lewis

doi:10.1126/science.1208344

Linking long-term dietary patterns with gut microbial enterotypes

Gary D. Wu, Jun Chen, Christian Hoffmann, Kyle Bittinger, Ying Yu Chen, Sue A. Keilbaugh, Meenakshi Bewtra, Dan Knights, William A. Walters, Rob Knight, Rohini Sinha, Erin Gilroy, Kernika Gupta, Robert Baldassano, Lisa Nessel, Hongzhe Li, Frederic D. Bushman, James D. Lewis

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

3285 Scopus citations

Abstract

Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet.

Original language	English (US)
Pages (from-to)	105-108
Number of pages	4
Journal	Science
Volume	334
Issue number	6052
DOIs	https://doi.org/10.1126/science.1208344
State	Published - Oct 7 2011

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Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y. Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., Sinha, R., Gilroy, E., Gupta, K., Baldassano, R., Nessel, L., Li, H., Bushman, F. D., & Lewis, J. D. (2011). Linking long-term dietary patterns with gut microbial enterotypes. Science, 334(6052), 105-108. https://doi.org/10.1126/science.1208344

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abstract = "Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet.",

author = "Wu, {Gary D.} and Jun Chen and Christian Hoffmann and Kyle Bittinger and Chen, {Ying Yu} and Keilbaugh, {Sue A.} and Meenakshi Bewtra and Dan Knights and Walters, {William A.} and Rob Knight and Rohini Sinha and Erin Gilroy and Kernika Gupta and Robert Baldassano and Lisa Nessel and Hongzhe Li and Bushman, {Frederic D.} and Lewis, {James D.}",

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AU - Chen, Jun

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AU - Keilbaugh, Sue A.

AU - Bewtra, Meenakshi

AU - Knights, Dan

AU - Walters, William A.

AU - Knight, Rob

AU - Sinha, Rohini

AU - Gilroy, Erin

AU - Gupta, Kernika

AU - Baldassano, Robert

AU - Nessel, Lisa

AU - Li, Hongzhe

AU - Bushman, Frederic D.

AU - Lewis, James D.

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AB - Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet.

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Linking long-term dietary patterns with gut microbial enterotypes

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