Linking long-term dietary patterns with gut microbial enterotypes

Gary D. Wu, Jun Chen, Christian Hoffmann, Kyle Bittinger, Ying Yu Chen, Sue A. Keilbaugh, Meenakshi Bewtra, Dan Knights, William A. Walters, Rob Knight, Rohini Sinha, Erin Gilroy, Kernika Gupta, Robert Baldassano, Lisa Nessel, Hongzhe Li, Frederic D. Bushman, James D. Lewis

Research output: Contribution to journalArticle

2355 Citations (Scopus)

Abstract

Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalScience
Volume334
Issue number6052
DOIs
StatePublished - Oct 7 2011
Externally publishedYes

Fingerprint

Prevotella
Diet
Bacteroides
Fats
Microbiota
High Fat Diet
Ribosomal DNA
Carbohydrates
Equipment and Supplies
Health
Proteins
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y. Y., Keilbaugh, S. A., ... Lewis, J. D. (2011). Linking long-term dietary patterns with gut microbial enterotypes. Science, 334(6052), 105-108. https://doi.org/10.1126/science.1208344

Linking long-term dietary patterns with gut microbial enterotypes. / Wu, Gary D.; Chen, Jun; Hoffmann, Christian; Bittinger, Kyle; Chen, Ying Yu; Keilbaugh, Sue A.; Bewtra, Meenakshi; Knights, Dan; Walters, William A.; Knight, Rob; Sinha, Rohini; Gilroy, Erin; Gupta, Kernika; Baldassano, Robert; Nessel, Lisa; Li, Hongzhe; Bushman, Frederic D.; Lewis, James D.

In: Science, Vol. 334, No. 6052, 07.10.2011, p. 105-108.

Research output: Contribution to journalArticle

Wu, GD, Chen, J, Hoffmann, C, Bittinger, K, Chen, YY, Keilbaugh, SA, Bewtra, M, Knights, D, Walters, WA, Knight, R, Sinha, R, Gilroy, E, Gupta, K, Baldassano, R, Nessel, L, Li, H, Bushman, FD & Lewis, JD 2011, 'Linking long-term dietary patterns with gut microbial enterotypes', Science, vol. 334, no. 6052, pp. 105-108. https://doi.org/10.1126/science.1208344
Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011 Oct 7;334(6052):105-108. https://doi.org/10.1126/science.1208344
Wu, Gary D. ; Chen, Jun ; Hoffmann, Christian ; Bittinger, Kyle ; Chen, Ying Yu ; Keilbaugh, Sue A. ; Bewtra, Meenakshi ; Knights, Dan ; Walters, William A. ; Knight, Rob ; Sinha, Rohini ; Gilroy, Erin ; Gupta, Kernika ; Baldassano, Robert ; Nessel, Lisa ; Li, Hongzhe ; Bushman, Frederic D. ; Lewis, James D. / Linking long-term dietary patterns with gut microbial enterotypes. In: Science. 2011 ; Vol. 334, No. 6052. pp. 105-108.
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