Linkages of nuclear architecture to biological and pathological control of gene expression

Gary S. Stein, Andre J van Wijnen, Janet L. Stein, Jane B. Lian, Shirwin M. Pockwinse, Sandra McNeil

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Functional interrelationships between components of nuclear architecture and control of gene expression are becoming increasingly evident. There is growing appreciation that multiple levels of nuclear organization integrate the regulatory cues that support activation and suppression of genes as well as the processing of gene transcripts. The linear organization of genes and promoter elements provide the potential for responsiveness to physiological regulatory signals. Parameters of chromatin structure and nucleosome organization support synergism between activities at independent regulatory sequences and render promoter elements accessible or refractory to transcription factors. Association of genes, transcription factors, and the machinery for transcript processing with the nuclear matrix facilitates fidelity of gene expression within the three-dimensional context of nuclear architecture. Mechanisms must be defined that couple nuclear morphology with enzymatic parameters of gene expression. The recent characterization of factors that mediate chromatin remodeling and intranuclear targeting signals that direct transcription factors to subnuclear domains where gene expression occurs, reflect linkage of genetic and structural components of transcriptional control. Nuclear reorganization and aberrant intranuclear trafficking of transcription factors for developmental and tissue-specific control that occurs in tumor cells and in neurological disorders provides a basis for high resolution diagnostics and targeted therapy.

Original languageEnglish (US)
Pages (from-to)220-231
Number of pages12
JournalJournal of Cellular Biochemistry
Issue numberSUPPL. 30/31
StatePublished - 1998
Externally publishedYes

Fingerprint

Gene expression
Transcription Factors
Genes
Gene Expression
Chromatin
Organizations
Nuclear Matrix
Genetic Linkage
Chromatin Assembly and Disassembly
Nucleosomes
Processing
Nervous System Diseases
Refractory materials
Transcriptional Activation
Machinery
Cues
Tumors
Chemical activation
Cells
Tissue

Keywords

  • Gene expression
  • Nuclear architecture
  • Tumor cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. M., & McNeil, S. (1998). Linkages of nuclear architecture to biological and pathological control of gene expression. Journal of Cellular Biochemistry, (SUPPL. 30/31), 220-231.

Linkages of nuclear architecture to biological and pathological control of gene expression. / Stein, Gary S.; van Wijnen, Andre J; Stein, Janet L.; Lian, Jane B.; Pockwinse, Shirwin M.; McNeil, Sandra.

In: Journal of Cellular Biochemistry, No. SUPPL. 30/31, 1998, p. 220-231.

Research output: Contribution to journalArticle

Stein, GS, van Wijnen, AJ, Stein, JL, Lian, JB, Pockwinse, SM & McNeil, S 1998, 'Linkages of nuclear architecture to biological and pathological control of gene expression', Journal of Cellular Biochemistry, no. SUPPL. 30/31, pp. 220-231.
Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse SM, McNeil S. Linkages of nuclear architecture to biological and pathological control of gene expression. Journal of Cellular Biochemistry. 1998;(SUPPL. 30/31):220-231.
Stein, Gary S. ; van Wijnen, Andre J ; Stein, Janet L. ; Lian, Jane B. ; Pockwinse, Shirwin M. ; McNeil, Sandra. / Linkages of nuclear architecture to biological and pathological control of gene expression. In: Journal of Cellular Biochemistry. 1998 ; No. SUPPL. 30/31. pp. 220-231.
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