Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

Nilufer Taner, Neill R Graff Radford, L. H. Younkin, C. Eckman, M. Baker, J. Adamson, J. Ronald, J. Blangero, M. Hutton, Steven G Younkin

Research output: Contribution to journalArticle

302 Citations (Scopus)

Abstract

Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.

Original languageEnglish (US)
Pages (from-to)2303-2304
Number of pages2
JournalScience
Volume290
Issue number5500
DOIs
StatePublished - Dec 22 2000

Fingerprint

Chromosomes, Human, Pair 10
Pedigree
Amyloid
Alzheimer Disease
Peptides
Lod Score
Siblings
Genome

ASJC Scopus subject areas

  • General

Cite this

Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. / Taner, Nilufer; Graff Radford, Neill R; Younkin, L. H.; Eckman, C.; Baker, M.; Adamson, J.; Ronald, J.; Blangero, J.; Hutton, M.; Younkin, Steven G.

In: Science, Vol. 290, No. 5500, 22.12.2000, p. 2303-2304.

Research output: Contribution to journalArticle

Taner, Nilufer ; Graff Radford, Neill R ; Younkin, L. H. ; Eckman, C. ; Baker, M. ; Adamson, J. ; Ronald, J. ; Blangero, J. ; Hutton, M. ; Younkin, Steven G. / Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. In: Science. 2000 ; Vol. 290, No. 5500. pp. 2303-2304.
@article{75dcb2b278b94396b3d79674c8b3bb0b,
title = "Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees",
abstract = "Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.",
author = "Nilufer Taner and {Graff Radford}, {Neill R} and Younkin, {L. H.} and C. Eckman and M. Baker and J. Adamson and J. Ronald and J. Blangero and M. Hutton and Younkin, {Steven G}",
year = "2000",
month = "12",
day = "22",
doi = "10.1126/science.290.5500.2303",
language = "English (US)",
volume = "290",
pages = "2303--2304",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5500",

}

TY - JOUR

T1 - Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

AU - Taner, Nilufer

AU - Graff Radford, Neill R

AU - Younkin, L. H.

AU - Eckman, C.

AU - Baker, M.

AU - Adamson, J.

AU - Ronald, J.

AU - Blangero, J.

AU - Hutton, M.

AU - Younkin, Steven G

PY - 2000/12/22

Y1 - 2000/12/22

N2 - Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.

AB - Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.

UR - http://www.scopus.com/inward/record.url?scp=0034703979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034703979&partnerID=8YFLogxK

U2 - 10.1126/science.290.5500.2303

DO - 10.1126/science.290.5500.2303

M3 - Article

C2 - 11125143

AN - SCOPUS:0034703979

VL - 290

SP - 2303

EP - 2304

JO - Science

JF - Science

SN - 0036-8075

IS - 5500

ER -