Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35

K. D. Mathews, K. A. Mills, E. P. Bosch, V. V. Ionasescu, K. R. Wiles, K. H. Buetow, J. C. Murray

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Fasioscapulohumeral muscular dystrophy (FSHD) has recently been localized to 4q35. We have studied four families with FSHD. Linkage to the 4q35 probes D4S163, D4S139, and D4S171 was confirmed. We found no recombinants helpful in detailed localization of the FSHD gene. Two of our families include males with a rapidly progressive muscle disease that had been diagnosed, on the basis of clinical features, as Duchenne muscular dystrophy. One of these males is available for linkage study and shares the haplotype of his FSHD-affected aunt and cousin.

Original languageEnglish (US)
Pages (from-to)428-431
Number of pages4
JournalAmerican Journal of Human Genetics
Volume51
Issue number2
StatePublished - Aug 1992
Externally publishedYes

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Facioscapulohumeral Muscular Dystrophy
Duchenne Muscular Dystrophy
Muscular Dystrophies
Haplotypes
Muscles
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Mathews, K. D., Mills, K. A., Bosch, E. P., Ionasescu, V. V., Wiles, K. R., Buetow, K. H., & Murray, J. C. (1992). Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35. American Journal of Human Genetics, 51(2), 428-431.

Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35. / Mathews, K. D.; Mills, K. A.; Bosch, E. P.; Ionasescu, V. V.; Wiles, K. R.; Buetow, K. H.; Murray, J. C.

In: American Journal of Human Genetics, Vol. 51, No. 2, 08.1992, p. 428-431.

Research output: Contribution to journalArticle

Mathews, KD, Mills, KA, Bosch, EP, Ionasescu, VV, Wiles, KR, Buetow, KH & Murray, JC 1992, 'Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35', American Journal of Human Genetics, vol. 51, no. 2, pp. 428-431.
Mathews KD, Mills KA, Bosch EP, Ionasescu VV, Wiles KR, Buetow KH et al. Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35. American Journal of Human Genetics. 1992 Aug;51(2):428-431.
Mathews, K. D. ; Mills, K. A. ; Bosch, E. P. ; Ionasescu, V. V. ; Wiles, K. R. ; Buetow, K. H. ; Murray, J. C. / Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35. In: American Journal of Human Genetics. 1992 ; Vol. 51, No. 2. pp. 428-431.
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