Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis

R. Patel, M. S. Rouse, K. E. Piper, J. M. Steckelberg

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log10 CFU per gram of vegetation after 3 days of treatment. The median log10 CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.

Original languageEnglish (US)
Pages (from-to)621-623
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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