Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis

R. Patel; M. S. Rouse; K. E. Piper; J. M. Steckelberg

doi:10.1128/AAC.45.2.621-623.2001

Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis

R. Patel, M. S. Rouse, K. E. Piper, J. M. Steckelberg

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log₁₀ CFU per gram of vegetation after 3 days of treatment. The median log₁₀ CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.

Original language	English (US)
Pages (from-to)	621-623
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	2
DOIs	https://doi.org/10.1128/AAC.45.2.621-623.2001
State	Published - 2001

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.45.2.621-623.2001

Cite this

@article{c8c4b9c850a84266b3c836e6aa6f4273,

title = "Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis",

abstract = "We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log10 CFU per gram of vegetation after 3 days of treatment. The median log10 CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.",

author = "R. Patel and Rouse, {M. S.} and Piper, {K. E.} and Steckelberg, {J. M.}",

year = "2001",

doi = "10.1128/AAC.45.2.621-623.2001",

language = "English (US)",

volume = "45",

pages = "621--623",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis

AU - Patel, R.

AU - Rouse, M. S.

AU - Piper, K. E.

AU - Steckelberg, J. M.

PY - 2001

Y1 - 2001

N2 - We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log10 CFU per gram of vegetation after 3 days of treatment. The median log10 CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.

AB - We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log10 CFU per gram of vegetation after 3 days of treatment. The median log10 CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.

UR - http://www.scopus.com/inward/record.url?scp=0035144830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035144830&partnerID=8YFLogxK

U2 - 10.1128/AAC.45.2.621-623.2001

DO - 10.1128/AAC.45.2.621-623.2001

M3 - Article

C2 - 11158767

AN - SCOPUS:0035144830

SN - 0066-4804

VL - 45

SP - 621

EP - 623

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this