Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis

Robin Patel, M. S. Rouse, K. E. Piper, J. M. Steckelberg

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log10 CFU per gram of vegetation after 3 days of treatment. The median log10 CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.

Original languageEnglish (US)
Pages (from-to)621-623
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number2
DOIs
StatePublished - 2001

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Linezolid
Enterococcus faecium
Vancomycin
Endocarditis
Body Weight
Therapeutics
Vancomycin-Resistant Enterococci

ASJC Scopus subject areas

  • Pharmacology (medical)

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Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis. / Patel, Robin; Rouse, M. S.; Piper, K. E.; Steckelberg, J. M.

In: Antimicrobial Agents and Chemotherapy, Vol. 45, No. 2, 2001, p. 621-623.

Research output: Contribution to journalArticle

Patel, Robin ; Rouse, M. S. ; Piper, K. E. ; Steckelberg, J. M. / Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis. In: Antimicrobial Agents and Chemotherapy. 2001 ; Vol. 45, No. 2. pp. 621-623.
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