Lineage switch in Philadelphia chromosome-positive acute lymphoblastic leukemia

D. A. Reardon, C. A. Hanson, M. S. Roth, V. P. Castle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background. An 8-year-old boy, initially diagnosed with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) (French- American-British [FAB] L1) relapsed with Ph+ acute myelogenous leukemia (AML) (FAB-M2) 21 months after successful ALL treatment with standard therapy. Methods. The initial ALL presentation and subsequent AML relapse were analyzed by conventional morphologic, cytochemical, immunophenotypic, and cytogenetic studies. Results. Molecular analysis based on the polymerase chain reaction identified the presence of a bcr-I-abl fusion transcript at initial ALL presentation, the completion of ALL therapy, and AML relapse. Conclusions. The cytogenetic and molecular results support a common clonal origin for this process. This is a case of lineage switch in a Ph+ acute leukemia. This case thus illustrates a manifestation of heterogeneous lineage differentiation among Ph+ acute leukemias.

Original languageEnglish (US)
Pages (from-to)1526-1532
Number of pages7
JournalCancer
Volume73
Issue number5
StatePublished - 1994
Externally publishedYes

Fingerprint

Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Cytogenetics
Leukemia
Recurrence
Therapeutics
Polymerase Chain Reaction

Keywords

  • bcr-I-abl fusion gene
  • heterogeneous differentiation
  • lineage switch
  • Philadelphia chromosome-positive acute leukemia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Reardon, D. A., Hanson, C. A., Roth, M. S., & Castle, V. P. (1994). Lineage switch in Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer, 73(5), 1526-1532.

Lineage switch in Philadelphia chromosome-positive acute lymphoblastic leukemia. / Reardon, D. A.; Hanson, C. A.; Roth, M. S.; Castle, V. P.

In: Cancer, Vol. 73, No. 5, 1994, p. 1526-1532.

Research output: Contribution to journalArticle

Reardon, DA, Hanson, CA, Roth, MS & Castle, VP 1994, 'Lineage switch in Philadelphia chromosome-positive acute lymphoblastic leukemia', Cancer, vol. 73, no. 5, pp. 1526-1532.
Reardon DA, Hanson CA, Roth MS, Castle VP. Lineage switch in Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer. 1994;73(5):1526-1532.
Reardon, D. A. ; Hanson, C. A. ; Roth, M. S. ; Castle, V. P. / Lineage switch in Philadelphia chromosome-positive acute lymphoblastic leukemia. In: Cancer. 1994 ; Vol. 73, No. 5. pp. 1526-1532.
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