Linaclotide in the management of gastrointestinal tract disorders

Brian E. Lacy, J. M. Levenick, M. D. Crowell

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Chronic constipation is a highly prevalent, heterogeneous disorder that significantly affects patients' lives. Nearly 15% of the U.S. population meets diagnostic criteria for chronic constipation (1). Chronic constipation reduces patients' quality of life and imposes a significant economic burden to the healthcare system (2, 3). A number of therapeutic options are currently available to treat symptoms of chronic constipation, although they are not universally successful (4, 5). Irritable bowel syndrome (IBS) is another common functional gastrointestinal disorder, with a prevalence rate estimated at up to 12% in the U.S. (6). Similar to chronic constipation, IBS imposes a significant impact on both the healthcare system and the individual patient (7-12). Currently, only one medication (lubiprostone) is approved by the U.S. Food and Drug Administration for the treatment of IBS with constipation (IBS-C), and is approved only for women (13). Although effective in many patients, it is not universally effective for the treatment of constipation symptoms in all patients with IBS-C. Other treatment options are therefore needed for those patients with chronic constipation and IBS-C who fail currently available therapies. This article will present information on the pharmacology and pharmacokinetics of linaclotide, a new agent designed to treat symptoms of both chronic constipation and IBS-C. Preclinical data, clinical studies and safety data will also be reviewed.

Original languageEnglish (US)
Pages (from-to)197-206
Number of pages10
JournalDrugs of Today
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Abdominal pain
  • Constipation
  • Guanylate cyclase
  • Irritable bowel syndrome
  • Linaclotide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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