Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors

Kenji Oritani, Kay L. Medina, Yoshiaki Tomiyama, Jun Ishikawa, Yu Okajima, Megumu Ogawa, Takahumi Yokota, Keisuke Aoyama, Isao Takahashi, Paul W. Kincade, Yuji Matsuzawa

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor- 1, it may represent a previously unknown type 1 interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.

Original languageEnglish (US)
Pages (from-to)659-666
Number of pages8
JournalNature Medicine
Volume6
Issue number6
DOIs
StatePublished - Jun 2000

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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