Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors

Kenji Oritani, Kay L Medina, Yoshiaki Tomiyama, Jun Ishikawa, Yu Okajima, Megumu Ogawa, Takahumi Yokota, Keisuke Aoyama, Isao Takahashi, Paul W. Kincade, Yuji Matsuzawa

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor- 1, it may represent a previously unknown type 1 interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.

Original languageEnglish (US)
Pages (from-to)659-666
Number of pages8
JournalNature Medicine
Volume6
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

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B-Lymphoid Precursor Cells
Lymphocytes
Interferons
Cytokines
Interferon Regulatory Factor-1
Janus Kinase 2
Interferon Receptors
Lymphopoiesis
Myelopoiesis
Interferon Type I
Erythropoiesis
Growth
Leukemia
Chemical activation
limitin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Oritani, K., Medina, K. L., Tomiyama, Y., Ishikawa, J., Okajima, Y., Ogawa, M., ... Matsuzawa, Y. (2000). Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors. Nature Medicine, 6(6), 659-666. https://doi.org/10.1038/76233

Limitin : An interferon-like cytokine that preferentially influences B- lymphocyte precursors. / Oritani, Kenji; Medina, Kay L; Tomiyama, Yoshiaki; Ishikawa, Jun; Okajima, Yu; Ogawa, Megumu; Yokota, Takahumi; Aoyama, Keisuke; Takahashi, Isao; Kincade, Paul W.; Matsuzawa, Yuji.

In: Nature Medicine, Vol. 6, No. 6, 06.2000, p. 659-666.

Research output: Contribution to journalArticle

Oritani, K, Medina, KL, Tomiyama, Y, Ishikawa, J, Okajima, Y, Ogawa, M, Yokota, T, Aoyama, K, Takahashi, I, Kincade, PW & Matsuzawa, Y 2000, 'Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors', Nature Medicine, vol. 6, no. 6, pp. 659-666. https://doi.org/10.1038/76233
Oritani, Kenji ; Medina, Kay L ; Tomiyama, Yoshiaki ; Ishikawa, Jun ; Okajima, Yu ; Ogawa, Megumu ; Yokota, Takahumi ; Aoyama, Keisuke ; Takahashi, Isao ; Kincade, Paul W. ; Matsuzawa, Yuji. / Limitin : An interferon-like cytokine that preferentially influences B- lymphocyte precursors. In: Nature Medicine. 2000 ; Vol. 6, No. 6. pp. 659-666.
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