Limb immobilization and corticobasal syndrome

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Recently, we evaluated two patients with corticobasal syndrome (CBS) who reported symptom onset after limb immobilization. Our objective was to investigate the association between trauma, immobilization and CBS. Methods: The charts of forty-four consecutive CBS patients seen in the Mayo Clinic Alzheimer Disease Research Center were reviewed with attention to trauma and limb immobilization. Results: 10 CBS patients (23%) had immobilization or trauma on the most affected limb preceding the onset or acceleration of symptoms. The median age at onset was 61. Six patients manifested their first symptoms after immobilization from surgery or fracture with one after leg trauma. Four patients had pre-existing symptoms of limb dysfunction but significantly worsened after immobilization or surgery. Conclusions: 23 percent of patients had immobilization or trauma of the affected limb. This might have implications for management of CBS, for avoiding injury, limiting immobilization and increasing movement in the affected limb.

Original languageEnglish (US)
Pages (from-to)1097-1099
Number of pages3
JournalParkinsonism and Related Disorders
Volume18
Issue number10
DOIs
StatePublished - Dec 2012

Fingerprint

Immobilization
Extremities
Wounds and Injuries
Age of Onset
Leg
Alzheimer Disease
Research

Keywords

  • Corticobasal syndrome
  • Immobilization
  • Plasticity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Limb immobilization and corticobasal syndrome. / Graff-Radford, Jonathan; Boeve, Bradley F; Drubach, Daniel; Knopman, David S; Ahlskog, J. Eric; Golden, Erin C.; Drubach, Dina I.; Petersen, Ronald Carl; Josephs, Keith Anthony.

In: Parkinsonism and Related Disorders, Vol. 18, No. 10, 12.2012, p. 1097-1099.

Research output: Contribution to journalArticle

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AU - Boeve, Bradley F

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AU - Knopman, David S

AU - Ahlskog, J. Eric

AU - Golden, Erin C.

AU - Drubach, Dina I.

AU - Petersen, Ronald Carl

AU - Josephs, Keith Anthony

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