Lifetime regulation of growth hormone (GH) secretion

Johannes D. Veldhuis, Ali Iranmanesh, Dana Erickson, Ferdinand Roelfsema, Cyril Y. Bowers

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Dynamic characteristics of the growth hormone (GH) axis are determined in part by developmental age, including fetal, neonatal, childhood, pubertal, young-adult and older-adult stages of life. The growth-promoting pituitary-dependent GH axis mediates soft-tissue and skeletal growth in puberty, and maintains body composition within relatively narrow bounds in puberty and adulthood. The hypothalamo-pituitary unit comprises a unique neuroendocrine interface, in which intermittent brain signals are delivered via a finite portal microvasculature to the multicellular anterior pituitary gland. The GHRH receptor is a GTP-dependent adenylyl cyclase-activating protein, with sequence homology to secretin and vasoactive intestinal polypeptide (VIP) receptors. The prototypical endogenous GHS is ghrelin, a 28-amino acid acylated peptide, which requires an octanoyl group esterified to serine in N-terminal position 3 for maximal receptor activation. Other fatty acyl groups can also confer bioactivity. Low pulsatile GH secretion in aged individuals may be reversed acutely by simultaneous administration of GHRH, GHS and L-arginine.

Original languageEnglish (US)
Title of host publicationHandbook of Neuroendocrinology
PublisherElsevier Inc.
Pages237-257
Number of pages21
ISBN (Print)9780123750976
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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    Veldhuis, J. D., Iranmanesh, A., Erickson, D., Roelfsema, F., & Bowers, C. Y. (2012). Lifetime regulation of growth hormone (GH) secretion. In Handbook of Neuroendocrinology (pp. 237-257). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-375097-6.10010-1