TY - JOUR
T1 - Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy
AU - Joseph, Richard W.
AU - Cappel, Mark
AU - Goedjen, Brent
AU - Gordon, Matthew
AU - Kirsch, Brandon
AU - Gilstrap, Cheryl
AU - Bagaria, Sanjay
AU - Jambusaria-Pahlajani, Anokhi
N1 - Publisher Copyright:
© 2014 American Association for Cancer Research.
PY - 2015/1
Y1 - 2015/1
N2 - Therapies that activate the immune system through blocking the binding of programmed death ligand 1 (PD-L1) present on tumors and PD-1 (programmed death 1) present on activated immune cells are revolutionizing the care for patients with cancer. These therapies work by inhibiting negative regulators of the immune system, thereby decreasing a tumor's ability to evade the immune system. The side effects of anti-PD-1/PD-L1 therapies are generally mild and as expected are related to autoimmune reactions. Two of the most common side effects of anti-PD-1/PD-L1 therapies are rash and pruritus occurring in approximately 20% of patients. Although the rash is generally recognized to be immune mediated, the exact mechanisms of the rash remain unclear. Herein, we report three cases of lichenoid dermatitis in three patients treated with MK-3475 (anti-PD-1) that were characterized with marked T-cell infiltrates with few PD-1-positive cells. The rashes in all three patients were relatively mild, allowing treatment to continue despite the rashes.
AB - Therapies that activate the immune system through blocking the binding of programmed death ligand 1 (PD-L1) present on tumors and PD-1 (programmed death 1) present on activated immune cells are revolutionizing the care for patients with cancer. These therapies work by inhibiting negative regulators of the immune system, thereby decreasing a tumor's ability to evade the immune system. The side effects of anti-PD-1/PD-L1 therapies are generally mild and as expected are related to autoimmune reactions. Two of the most common side effects of anti-PD-1/PD-L1 therapies are rash and pruritus occurring in approximately 20% of patients. Although the rash is generally recognized to be immune mediated, the exact mechanisms of the rash remain unclear. Herein, we report three cases of lichenoid dermatitis in three patients treated with MK-3475 (anti-PD-1) that were characterized with marked T-cell infiltrates with few PD-1-positive cells. The rashes in all three patients were relatively mild, allowing treatment to continue despite the rashes.
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U2 - 10.1158/2326-6066.CIR-14-0134
DO - 10.1158/2326-6066.CIR-14-0134
M3 - Article
C2 - 25287118
AN - SCOPUS:84939470051
SN - 2326-6066
VL - 3
SP - 18
EP - 22
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 1
ER -