Lewy bodies of Parkinson's disease contain neurofilament antigens

J. E. Goldman, S. H. Yen, F. C. Chui, N. S. Peress

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)1082-1084
Number of pages3
JournalScience
Volume221
Issue number4615
StatePublished - 1983
Externally publishedYes

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Lewy Bodies
Intermediate Filaments
Parkinson Disease
Antigens
Cytoskeleton
Nervous System
Brain Stem
Immune Sera
Neurons
Proteins

ASJC Scopus subject areas

  • General

Cite this

Goldman, J. E., Yen, S. H., Chui, F. C., & Peress, N. S. (1983). Lewy bodies of Parkinson's disease contain neurofilament antigens. Science, 221(4615), 1082-1084.

Lewy bodies of Parkinson's disease contain neurofilament antigens. / Goldman, J. E.; Yen, S. H.; Chui, F. C.; Peress, N. S.

In: Science, Vol. 221, No. 4615, 1983, p. 1082-1084.

Research output: Contribution to journalArticle

Goldman, JE, Yen, SH, Chui, FC & Peress, NS 1983, 'Lewy bodies of Parkinson's disease contain neurofilament antigens', Science, vol. 221, no. 4615, pp. 1082-1084.
Goldman JE, Yen SH, Chui FC, Peress NS. Lewy bodies of Parkinson's disease contain neurofilament antigens. Science. 1983;221(4615):1082-1084.
Goldman, J. E. ; Yen, S. H. ; Chui, F. C. ; Peress, N. S. / Lewy bodies of Parkinson's disease contain neurofilament antigens. In: Science. 1983 ; Vol. 221, No. 4615. pp. 1082-1084.
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