Lewy bodies of Parkinson's disease contain neurofilament antigens

James E. Goldman; Shu Hui Yen; Fung Chow Chiu; Nancy S. Peress

doi:10.1126/science.6308771

Lewy bodies of Parkinson's disease contain neurofilament antigens

James E. Goldman, Shu Hui Yen, Fung Chow Chiu, Nancy S. Peress

Neuroscience

Research output: Contribution to journal › Article › peer-review

197 Scopus citations

Abstract

The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.

Original language	English (US)
Pages (from-to)	1082-1084
Number of pages	3
Journal	Science
Volume	221
Issue number	4615
DOIs	https://doi.org/10.1126/science.6308771
State	Published - 1983

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title = "Lewy bodies of Parkinson's disease contain neurofilament antigens",

abstract = "The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.",

author = "Goldman, {James E.} and Yen, {Shu Hui} and Chiu, {Fung Chow} and Peress, {Nancy S.}",

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T1 - Lewy bodies of Parkinson's disease contain neurofilament antigens

AU - Goldman, James E.

AU - Yen, Shu Hui

AU - Chiu, Fung Chow

AU - Peress, Nancy S.

PY - 1983

Y1 - 1983

N2 - The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.

AB - The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.

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Lewy bodies of Parkinson's disease contain neurofilament antigens

Abstract

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