Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls

Y. Tsuboi, J. E. Ahlskog, H. Apaydin, J. E. Parisi, Dennis W. Dickson

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Objective: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). Background: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. Methods: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98 normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for α-synuclein. Results: LB and Lewy neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was comparable to the frequency of LB in controls (9%). Conclusions: In contrast to increased frequency of LB in AD, there is no apparent interaction between LB and the tau pathology in PSP.

Original languageEnglish (US)
Pages (from-to)1675-1678
Number of pages4
JournalNeurology
Volume57
Issue number9
DOIs
StatePublished - Nov 13 2001

ASJC Scopus subject areas

  • Clinical Neurology

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