Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls

Y. Tsuboi, J. E. Ahlskog, H. Apaydin, Joseph E Parisi, Dennis W Dickson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). Background: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. Methods: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98 normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for α-synuclein. Results: LB and Lewy neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was comparable to the frequency of LB in controls (9%). Conclusions: In contrast to increased frequency of LB in AD, there is no apparent interaction between LB and the tau pathology in PSP.

Original languageEnglish (US)
Pages (from-to)1675-1678
Number of pages4
JournalNeurology
Volume57
Issue number9
StatePublished - Nov 13 2001

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Progressive Supranuclear Palsy
Lewy Bodies
Neurites
Substantia Nigra
Synucleins
Amygdala
Neurodegenerative Diseases
Immunohistochemistry
Pathology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tsuboi, Y., Ahlskog, J. E., Apaydin, H., Parisi, J. E., & Dickson, D. W. (2001). Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls. Neurology, 57(9), 1675-1678.

Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls. / Tsuboi, Y.; Ahlskog, J. E.; Apaydin, H.; Parisi, Joseph E; Dickson, Dennis W.

In: Neurology, Vol. 57, No. 9, 13.11.2001, p. 1675-1678.

Research output: Contribution to journalArticle

Tsuboi, Y, Ahlskog, JE, Apaydin, H, Parisi, JE & Dickson, DW 2001, 'Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls', Neurology, vol. 57, no. 9, pp. 1675-1678.
Tsuboi Y, Ahlskog JE, Apaydin H, Parisi JE, Dickson DW. Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls. Neurology. 2001 Nov 13;57(9):1675-1678.
Tsuboi, Y. ; Ahlskog, J. E. ; Apaydin, H. ; Parisi, Joseph E ; Dickson, Dennis W. / Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls. In: Neurology. 2001 ; Vol. 57, No. 9. pp. 1675-1678.
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