Levosimendan in Cardiac Surgery: Evaluating the Evidence

Shaji A. Faisal; David A. Apatov; Harish Ramakrishna; Menachem M. Weiner

doi:10.1053/j.jvca.2018.05.035

Levosimendan in Cardiac Surgery: Evaluating the Evidence

Shaji A. Faisal, David A. Apatov, Harish Ramakrishna, Menachem M. Weiner

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The evidence supporting the use of levosimendan in the cardiac surgical perioperative period is not well-established. Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted. This review examines the physiological and pharmacologic properties of levosimendan and evaluates the literature regarding the use of levosimendan in patients undergoing cardiac surgery.

Original language	English (US)
Pages (from-to)	1146-1158
Number of pages	13
Journal	Journal of Cardiothoracic and Vascular Anesthesia
Volume	33
Issue number	4
DOIs	https://doi.org/10.1053/j.jvca.2018.05.035
State	Published - Apr 2019

Keywords

cardiac surgery
inotropes
levosimendan
low cardiac output syndrome

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Anesthesiology and Pain Medicine

Access to Document

10.1053/j.jvca.2018.05.035

Cite this

@article{f592d2ab69034e0ca817ed6df8651b71,

title = "Levosimendan in Cardiac Surgery: Evaluating the Evidence",

abstract = "Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The evidence supporting the use of levosimendan in the cardiac surgical perioperative period is not well-established. Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted. This review examines the physiological and pharmacologic properties of levosimendan and evaluates the literature regarding the use of levosimendan in patients undergoing cardiac surgery.",

keywords = "cardiac surgery, inotropes, levosimendan, low cardiac output syndrome",

author = "Faisal, {Shaji A.} and Apatov, {David A.} and Harish Ramakrishna and Weiner, {Menachem M.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = apr,

doi = "10.1053/j.jvca.2018.05.035",

language = "English (US)",

volume = "33",

pages = "1146--1158",

journal = "Journal of Cardiothoracic and Vascular Anesthesia",

issn = "1053-0770",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Levosimendan in Cardiac Surgery

T2 - Evaluating the Evidence

AU - Faisal, Shaji A.

AU - Apatov, David A.

AU - Ramakrishna, Harish

AU - Weiner, Menachem M.

PY - 2019/4

Y1 - 2019/4

N2 - Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The evidence supporting the use of levosimendan in the cardiac surgical perioperative period is not well-established. Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted. This review examines the physiological and pharmacologic properties of levosimendan and evaluates the literature regarding the use of levosimendan in patients undergoing cardiac surgery.

AB - Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The evidence supporting the use of levosimendan in the cardiac surgical perioperative period is not well-established. Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted. This review examines the physiological and pharmacologic properties of levosimendan and evaluates the literature regarding the use of levosimendan in patients undergoing cardiac surgery.

KW - cardiac surgery

KW - inotropes

KW - levosimendan

KW - low cardiac output syndrome

UR - http://www.scopus.com/inward/record.url?scp=85050363390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050363390&partnerID=8YFLogxK

U2 - 10.1053/j.jvca.2018.05.035

DO - 10.1053/j.jvca.2018.05.035

M3 - Review article

C2 - 30055988

AN - SCOPUS:85050363390

SN - 1053-0770

VL - 33

SP - 1146

EP - 1158

JO - Journal of Cardiothoracic and Vascular Anesthesia

JF - Journal of Cardiothoracic and Vascular Anesthesia

IS - 4

ER -

Levosimendan in Cardiac Surgery: Evaluating the Evidence

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this