Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Leon M. Tai, Tina Bilousova, Lisa Jungbauer, Stephen K. Roeske, Katherine L. Youmans, Chunjiang Yu, Wayne W. Poon, Lindsey B. Cornwell, Carol A. Miller, Harry V. Vinters, Linda J. Van Eldik, David W. Fardo, Steve Estus, Guojun Bu, Karen Hoppens Gylys, Mary Jo LaDu

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.

Original languageEnglish (US)
Pages (from-to)5914-5926
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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