Leukodystrophy

M. C. Patterson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The term leukodystrophy is generally employed to describe a large and growing family of progressive genetic disorders that cause dysmyelination, demyelination, or both in the central nervous system. Leukodystrophies may result from primary or secondary enzyme deficiencies, or from novel mechanisms, such as impaired regulation of protein translation. Disease-modifying therapy is available for only a few of these disorders, but several experimental approaches are under investigation.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages876-877
Number of pages2
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Adrenoleukodystrophy
  • Alexander
  • Canavan
  • Krabbe
  • Leukodystrophy
  • Lysosomal storage disorders
  • Metachromatic leukodystrophy
  • Myelin
  • Pelizaeus-Merzbacher
  • Peroxisomal
  • White matter

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patterson, M. C. (2014). Leukodystrophy. In Encyclopedia of the Neurological Sciences (pp. 876-877). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00085-3