Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a common form of renal amyloidosis among Egyptians

Christopher P. Larsen, Wesam Ismail, Paul J. Kurtin, Julie A. Vrana, Surendra Dasari, Samih H. Nasr

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Large case series of renal amyloidosis subtypes have recently been published in the United States and Europe showing AL amyloidosis to be the predominant subtype in this part of the world. However, the most common subtypes of renal amyloidosis throughout the rest of the world are unknown. We present here the first large case series detailing the subtypes of renal amyloidosis among Egyptians. In this population, AA amyloidosis was the most common type of amyloidosis on renal biopsy at 48%. The newly described leukocyte chemotactic factor 2 amyloidosis (ALECT2) was the second most common type and represented nearly one-third of renal amyloid cases at 31%. AL accounted for only 20% of cases. The pathologic findings in ALECT2 cases were similar to those previously described in other case series. Thus ALECT2, which was initially thought to affect mainly Hispanics in the United States, appears to represent an important and likely underrecognized etiology of chronic kidney disease among Egyptians and probably in other ethnic groups around the world.Modern Pathology advance online publication, 12 February 2016; doi:10.1038/modpathol.2016.29.

Original languageEnglish (US)
JournalModern Pathology
DOIs
StateAccepted/In press - Feb 12 2016

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Chemotactic Factors
Amyloidosis
Leukocytes
Kidney
Chronic Renal Insufficiency
Hispanic Americans
Ethnic Groups
Amyloid
Publications
Pathology
Biopsy
Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a common form of renal amyloidosis among Egyptians. / Larsen, Christopher P.; Ismail, Wesam; Kurtin, Paul J.; Vrana, Julie A.; Dasari, Surendra; Nasr, Samih H.

In: Modern Pathology, 12.02.2016.

Research output: Contribution to journalArticle

Larsen, Christopher P. ; Ismail, Wesam ; Kurtin, Paul J. ; Vrana, Julie A. ; Dasari, Surendra ; Nasr, Samih H. / Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a common form of renal amyloidosis among Egyptians. In: Modern Pathology. 2016.
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