Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States

Oana M. Mereuta, Jason D. Theis, Julie A. Vrana, Mark E. Law, Karen L. Grogg, Surendra Dasari, Vishal S. Chandan, Tsung Teh Wu, Victor H. Jimenez-Zepeda, Rafael Fonseca, Angela Dispenzieri, Paul J. Kurtin, Ahmet Dogan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Using laser microdissection and mass spectrometry (MS)-based proteomics, we subtyped amyloid deposits from 130 cases of hepatic amyloidosis. Although we confirmed that immunoglobulin light chain amyloidosis was the most frequent cause of hepatic amyloidosis, leukocyte cell-derived chemotaxin 2 (LECT2) amyloidosis (ALect2) accounted for 25% of cases. This novel finding was associated with Hispanic ancestry, incidental discovery of amyloid in liver specimens sampled for other unrelated conditions, and a characteristic pattern of hepatic amyloid deposition. Although ALect2 patients had a common LECT2 polymorphism, pathogenic mutations were not discovered, suggesting that constitutive or compensatory LECT2 overexpression led to ALect2 deposition. These findings indicate that ALect2 is a common cause of hepatic amyloidosis in the population of the United States, and subtyping hepatic amyloid deposits by an accurate analytic method such as MS is required for optimal clinical management of hepatic amyloidosis patients and to avoid incorrect and unnecessarily toxic therapies.

Original languageEnglish (US)
Pages (from-to)1479-1482
Number of pages4
JournalBlood
Volume123
Issue number10
DOIs
StatePublished - Mar 6 2014

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Chemotactic Factors
Amyloidosis
Amyloid
Leukocytes
Liver
Mass spectrometry
Microdissection
Deposits
Immunoglobulin Light Chains
Amyloid Plaques
Poisons
Polymorphism
Mass Spectrometry
Incidental Findings
Lasers
Hispanic Americans
Proteomics
Mutation
Population

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States. / Mereuta, Oana M.; Theis, Jason D.; Vrana, Julie A.; Law, Mark E.; Grogg, Karen L.; Dasari, Surendra; Chandan, Vishal S.; Wu, Tsung Teh; Jimenez-Zepeda, Victor H.; Fonseca, Rafael; Dispenzieri, Angela; Kurtin, Paul J.; Dogan, Ahmet.

In: Blood, Vol. 123, No. 10, 06.03.2014, p. 1479-1482.

Research output: Contribution to journalArticle

Mereuta, OM, Theis, JD, Vrana, JA, Law, ME, Grogg, KL, Dasari, S, Chandan, VS, Wu, TT, Jimenez-Zepeda, VH, Fonseca, R, Dispenzieri, A, Kurtin, PJ & Dogan, A 2014, 'Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States', Blood, vol. 123, no. 10, pp. 1479-1482. https://doi.org/10.1182/blood-2013-07-517938
Mereuta, Oana M. ; Theis, Jason D. ; Vrana, Julie A. ; Law, Mark E. ; Grogg, Karen L. ; Dasari, Surendra ; Chandan, Vishal S. ; Wu, Tsung Teh ; Jimenez-Zepeda, Victor H. ; Fonseca, Rafael ; Dispenzieri, Angela ; Kurtin, Paul J. ; Dogan, Ahmet. / Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States. In: Blood. 2014 ; Vol. 123, No. 10. pp. 1479-1482.
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