Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C. G. Brunstein, B. A. Hirsch, D. Hammerschmidt, R. C. McGlennen, P. L. Nguyen, C. M. Verfaillie

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

Original languageEnglish (US)
Pages (from-to)999-1003
Number of pages5
JournalBone Marrow Transplantation
Volume29
Issue number12
DOIs
StatePublished - 2002

Keywords

  • Acute myeloid luekemia
  • Allogeneic hematopoietic stem cell transplant
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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