Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C. G. Brunstein, B. A. Hirsch, D. Hammerschmidt, R. C. McGlennen, P. L. Nguyen, C. M. Verfaillie

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

Original languageEnglish (US)
Pages (from-to)999-1003
Number of pages5
JournalBone Marrow Transplantation
Volume29
Issue number12
DOIs
StatePublished - Jan 1 2002

Keywords

  • Acute myeloid luekemia
  • Allogeneic hematopoietic stem cell transplant
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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  • Cite this

    Brunstein, C. G., Hirsch, B. A., Hammerschmidt, D., McGlennen, R. C., Nguyen, P. L., & Verfaillie, C. M. (2002). Leukemia in donor cells after allogeneic hematopoietic stem cell transplant. Bone Marrow Transplantation, 29(12), 999-1003. https://doi.org/10.1038/sj.bmt.1703577