Leucine, glucose, and energy metabolism after 3 days of fasting in healthy human subjects

K. Steekumaran Nair, P. D. Woolf, S. L. Welle, D. E. Matthews

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Adaptations of leucine and glucose metabolism to 3 d of fasting were examined in six healthy young men by use of L-[1-13C]leucine and D[6,6-2H2]glucose as tracers. Leucine flux increased 31% and leucine oxidation increased 46% after 3 d of fasting compared with leucine flux and oxidation after an overnight fast. Glucose production rate declined 38% and resting metabolic rate decreased 8% during fasting. Plasma concentrations of testosterone, insulin, and triiodothyronine were reduced by fasting whereas plasma glucagon concentrations were increased. We conclude that there is increased proteolysis and oxidation of leucine on short term fasting even though glucose production and energy expenditure decreased.

Original languageEnglish (US)
Pages (from-to)557-562
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume46
Issue number4
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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