Abstract
Vitamin Ds non-skeletal actions, including immunomodulatory role, have been increasingly recognized. Of significance, many immune cells are able to synthesize a biologically active form of vitamin D from circulating 25-hydroxyvitamin D with subsequent intracrine actions, and the vitamin D receptor is broadly distributed. In this review, we discuss vitamin Ds potent role in innate and adaptive immune responses and published studies evaluating the impact of serum vitamin D, vitamin D gene pathway polymorphisms or empiric vitamin D supplementation on vaccine immunogenicity. We highlight existing knowledge gaps and propose the steps needed to advance the science and answer the question of whether vitamin D may prove valuable as a vaccine adjuvant for certain vaccines against infectious diseases.
Original language | English (US) |
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Pages (from-to) | 1427-1440 |
Number of pages | 14 |
Journal | Expert review of vaccines |
Volume | 14 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2 2015 |
Keywords
- Vitamin D
- adaptive immunity
- cellular immunity
- immunization
- innate immunity
- vaccines
ASJC Scopus subject areas
- Immunology
- Molecular Medicine
- Pharmacology
- Drug Discovery