Less death in the dying

Kornelia Polyak; Tsung Teh Wu; Stanley R. Hamilton; Kenneth W. Kinzler; Bert Vogelstein

doi:10.1038/sj.cdd.4400226

Less death in the dying

Kornelia Polyak, Tsung Teh Wu, Stanley R. Hamilton, Kenneth W. Kinzler, Bert Vogelstein

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Diseases associated with aging are now the primary causes of death in developed countries. This is in part due to the long recognized exponential association of cancer with age and perhaps to a deterioration of the immune system with advanced age. Both prevention of tumorigenesis and immune function are critically dependent on apoptosis. In this study we examined apoptosis in mice of various age following gamma irradiation. We found a striking age-dependent decrease in radiation-induced apoptosis in splenic lymphocytes but not in colorectal epithelial cells. These observations may therefore provide a clue to the decline of immune function with age.

Original language	English (US)
Pages (from-to)	242-246
Number of pages	5
Journal	Cell Death and Differentiation
Volume	4
Issue number	3
DOIs	https://doi.org/10.1038/sj.cdd.4400226
State	Published - Apr 1997

Keywords

Aging
Apoptosis
Immune system
Radiation

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/sj.cdd.4400226

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title = "Less death in the dying",

abstract = "Diseases associated with aging are now the primary causes of death in developed countries. This is in part due to the long recognized exponential association of cancer with age and perhaps to a deterioration of the immune system with advanced age. Both prevention of tumorigenesis and immune function are critically dependent on apoptosis. In this study we examined apoptosis in mice of various age following gamma irradiation. We found a striking age-dependent decrease in radiation-induced apoptosis in splenic lymphocytes but not in colorectal epithelial cells. These observations may therefore provide a clue to the decline of immune function with age.",

keywords = "Aging, Apoptosis, Immune system, Radiation",

author = "Kornelia Polyak and Wu, {Tsung Teh} and Hamilton, {Stanley R.} and Kinzler, {Kenneth W.} and Bert Vogelstein",

note = "Funding Information: We thank Jim Flook for expert assistance with flow cytometric analysis. This work was supported by the Clayton Fund and NIH grants CA35494, CA 43460, CA57345, and CA62924. B.V. is an investigator of the Howard Hughes Medical Institute.",

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AU - Polyak, Kornelia

AU - Wu, Tsung Teh

AU - Hamilton, Stanley R.

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

N1 - Funding Information: We thank Jim Flook for expert assistance with flow cytometric analysis. This work was supported by the Clayton Fund and NIH grants CA35494, CA 43460, CA57345, and CA62924. B.V. is an investigator of the Howard Hughes Medical Institute.

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AB - Diseases associated with aging are now the primary causes of death in developed countries. This is in part due to the long recognized exponential association of cancer with age and perhaps to a deterioration of the immune system with advanced age. Both prevention of tumorigenesis and immune function are critically dependent on apoptosis. In this study we examined apoptosis in mice of various age following gamma irradiation. We found a striking age-dependent decrease in radiation-induced apoptosis in splenic lymphocytes but not in colorectal epithelial cells. These observations may therefore provide a clue to the decline of immune function with age.

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KW - Immune system

KW - Radiation

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Less death in the dying

Abstract

Keywords

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