Lesion Dynamics Under Varying Paracrine PDGF Signaling in Brain Tissue

Susan Christine Massey, Andrea Hawkins-Daarud, Jill Gallaher, Alexander R.A. Anderson, Peter Canoll, Kristin Swanson

Research output: Contribution to journalArticle

Abstract

Paracrine PDGF signaling is involved in many processes in the body, both normal and pathological, including embryonic development, angiogenesis, and wound healing as well as liver fibrosis, atherosclerosis, and cancers. We explored this seemingly dual (normal and pathological) role of PDGF mathematically by modeling the release of PDGF in brain tissue and then varying the dynamics of this release. Resulting simulations show that by varying the dynamics of a PDGF source, our model predicts three possible outcomes for PDGF-driven cellular recruitment and lesion growth: (1) localized, short duration of growth, (2) localized, chronic growth, and (3) widespread chronic growth. Further, our model predicts that the type of response is much more sensitive to the duration of PDGF exposure than the maximum level of that exposure. This suggests that extended duration of paracrine PDGF signal during otherwise normal processes could potentially lead to lesions having a phenotype consistent with pathologic conditions.

Original languageEnglish (US)
JournalBulletin of Mathematical Biology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Paracrine Communication
lesion
lesions (animal)
brain
Brain
Tissue
duration
Growth
liver cirrhosis
angiogenesis
Wound Healing
tissue repair
atherosclerosis
Atherosclerosis
Fibrosis
Angiogenesis
Predict
embryonic development
embryogenesis
Liver Neoplasms

Keywords

  • Gliosis
  • Oligodendroglial progenitors
  • Platelet-derived growth factor
  • Scarring

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

Cite this

Lesion Dynamics Under Varying Paracrine PDGF Signaling in Brain Tissue. / Massey, Susan Christine; Hawkins-Daarud, Andrea; Gallaher, Jill; Anderson, Alexander R.A.; Canoll, Peter; Swanson, Kristin.

In: Bulletin of Mathematical Biology, 01.01.2019.

Research output: Contribution to journalArticle

Massey, Susan Christine ; Hawkins-Daarud, Andrea ; Gallaher, Jill ; Anderson, Alexander R.A. ; Canoll, Peter ; Swanson, Kristin. / Lesion Dynamics Under Varying Paracrine PDGF Signaling in Brain Tissue. In: Bulletin of Mathematical Biology. 2019.
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