Leptomeningeal metastases of solid cancer

Emilie Le Rhun, Evanthia Galanis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: To review recent original data on leptomeningeal metastases in patients with solid cancer. RECENT FINDINGS: Lung and breast cancer as well as melanoma remain the most common primaries. Advanced cytological methods and targeted sequencing for candidate tumor-specific mutations may improve the sensitivity of cerebrospinal fluid diagnostics in leptomeningeal metastases. Targeted treatments like epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer, anti-human epidermal growth factor receptor-2 treatments for breast cancer or B-rapidly accelerated fibrosarcoma-targeted or immunotherapy for melanoma have an emerging role in the management of this condition. SUMMARY: Novel diagnostic approaches and the introduction of targeted agents may improve the clinical management of patients with leptomeningeal metastases from solid cancers.

Original languageEnglish (US)
JournalCurrent Opinion in Neurology
DOIs
StateAccepted/In press - Sep 22 2016

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Neoplasm Metastasis
Melanoma
Breast Neoplasms
Neoplasms
Fibrosarcoma
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Immunotherapy
Cerebrospinal Fluid
Lung Neoplasms
Mutation
Therapeutics
human ERBB2 protein

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Leptomeningeal metastases of solid cancer. / Le Rhun, Emilie; Galanis, Evanthia.

In: Current Opinion in Neurology, 22.09.2016.

Research output: Contribution to journalArticle

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