Leptomeningeal artery atherosclerosis visualized by angiography: Clinical correlates

David S. Knopman, David C. Anderson, Angeline Mastri, David Larson

Research output: Contribution to journalArticlepeer-review

Abstract

Circumscribed atherosclerotic involvement of secondary and tertiary branches of major cerebral arteries is a common angiographic finding whose nature is rarely in question. However, widespread and severe changes are unusual, and radiologic interpretation may be more difficult. We recently cared for a patient whose angiogram demonstrated extensive involvement of leptomeningeal vessels and were prompted to review the clinical courses and autopsy findings of a number of other patients with similar angiographic findings. Our observations suggest that the radiological appearance of leptomeningeal artery atherosclerosis can be confused with that of an arteritis. Atherosclerosis of leptomeningeal arteries is strongly associated with a history of arterial hypertension and seems to parallel arterial lesions thought responsible for lacunar infarction and intraparenchymal hemorrhage.

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalStroke
Volume9
Issue number3
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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