Leptin receptor immunoreactivity in sympathetic prevertebral ganglion neurons of mouse and rat

Steven M. Miller, Philip F. Schmalz, Eduardo E. Benarroch, Joseph H. Szurszewski

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Prevertebral ganglia, comprising the inferior mesenteric, superior mesenteric and celiac ganglia, contain the cell bodies of sympathetic neurons that regulate gastrointestinal motility, visceral blood flow, secretion and absorption. In the present study, we report the presence of leptin receptor- like immunoreactivity in the superior mesenteric and celiac ganglia of mice and rats. Ganglion neurons were immunopositive for leptin receptor. Confocal microscopy and three-dimensional (3-D) reconstruction of ganglion neurons filled with Lucifer yellow and then immunostained for leptin receptor showed that leptin receptor immunoreactivity was intracellular and that it was present on structures encircling the nucleus. These results raise the possibility that leptin may affect gastrointestinal function by acting on leptin receptors located in prevertebral ganglion neurons.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalNeuroscience Letters
Volume265
Issue number2
DOIs
StatePublished - Apr 16 1999

Keywords

  • Immunohistochemistry
  • Leptin receptors
  • Obesity
  • Prevertebral ganglia
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neuroscience(all)

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