TY - JOUR
T1 - Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects
AU - Narkiewicz, Krzysztof
AU - Kato, Masahiko
AU - Phillips, Bradley G.
AU - Pesek, Catherine A.
AU - Choe, Ian
AU - Winnicki, Mikolaj
AU - Palatini, Paolo
AU - Sivitz, William I.
AU - Somers, Virend K.
PY - 2001
Y1 - 2001
N2 - Objective: Administration of leptin to animals increases sympathetic nerve activity and heart rate. We therefore tested the hypothesis that plasma leptin is linked independently to muscle sympathetic nerve activity (MSNA) and heart rate in healthy humans. Methods: We measured plasma leptin, plasma insulin, body mass index (BMI), percent body fat, waist:hip ratio, MSNA, heart rate and blood pressure in 88 healthy individuals (50 men and 38 women). Results: In men, plasma leptin concentration correlated significantly with BM I (r = 0.75, P < 0.001), percent body fat (r = 0.70, P < 0.001), waist:hip ratio (r = 0.69, P < 0.001), insulin (r= 0.37, P= 0.009), and age (r= 0.38, P= 0.006). Only BMI and waist: hip ratio were linked independently to plasma leptin concentration (r = 0.78, P < 0.001). Plasma leptin concentrations also correlated with heart rate (r= 0.39, P= 0.006) and mean arterial pressure (MAP; r= 0.38, P= 0.007), but not with MSNA (r= 0.17, P= 0.24). After adjustment for BMI and waist:hip ratio, plasma leptin concentration correlated significantly only with heart rate (r= 0.29, P= 0.04), and not with MAP (r= 0.21, P= 0.14). Individuals were divided into high-leptin and low-leptin subgroups on the basis of plasma leptin concentrations adjusted for BMI and waist:hip ratio. Those with high leptin concentrations had significantly faster heart rates than those with low leptin. MAP and MSNA were similar in both subgroups. No relationship between leptin and either heart rate or MSNA was evident in women. Conclusions: In normal men, heart rate, but not MSNA, is linked to plasma leptin concentration. This sex-specific relationship between heart rate and plasma leptin is independent of plasma insulin, BMI, waist: hip ratio and percentage body fat.
AB - Objective: Administration of leptin to animals increases sympathetic nerve activity and heart rate. We therefore tested the hypothesis that plasma leptin is linked independently to muscle sympathetic nerve activity (MSNA) and heart rate in healthy humans. Methods: We measured plasma leptin, plasma insulin, body mass index (BMI), percent body fat, waist:hip ratio, MSNA, heart rate and blood pressure in 88 healthy individuals (50 men and 38 women). Results: In men, plasma leptin concentration correlated significantly with BM I (r = 0.75, P < 0.001), percent body fat (r = 0.70, P < 0.001), waist:hip ratio (r = 0.69, P < 0.001), insulin (r= 0.37, P= 0.009), and age (r= 0.38, P= 0.006). Only BMI and waist: hip ratio were linked independently to plasma leptin concentration (r = 0.78, P < 0.001). Plasma leptin concentrations also correlated with heart rate (r= 0.39, P= 0.006) and mean arterial pressure (MAP; r= 0.38, P= 0.007), but not with MSNA (r= 0.17, P= 0.24). After adjustment for BMI and waist:hip ratio, plasma leptin concentration correlated significantly only with heart rate (r= 0.29, P= 0.04), and not with MAP (r= 0.21, P= 0.14). Individuals were divided into high-leptin and low-leptin subgroups on the basis of plasma leptin concentrations adjusted for BMI and waist:hip ratio. Those with high leptin concentrations had significantly faster heart rates than those with low leptin. MAP and MSNA were similar in both subgroups. No relationship between leptin and either heart rate or MSNA was evident in women. Conclusions: In normal men, heart rate, but not MSNA, is linked to plasma leptin concentration. This sex-specific relationship between heart rate and plasma leptin is independent of plasma insulin, BMI, waist: hip ratio and percentage body fat.
KW - Heart rate
KW - Hypertension
KW - Leptin
KW - Sympathetic nervous system
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U2 - 10.1097/00004872-200106000-00014
DO - 10.1097/00004872-200106000-00014
M3 - Article
C2 - 11403358
AN - SCOPUS:0035017407
SN - 0263-6352
VL - 19
SP - 1089
EP - 1094
JO - Journal of hypertension
JF - Journal of hypertension
IS - 6
ER -