Leptin and the hypothalamo-pituitary-adrenal stress axis

Eric W. Roubos, Maurice Dahmen, Tamas Kozicz, Lu Xu

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

Leptin is a 16-kDa protein mainly produced and secreted by white adipose tissue and informing various brain centers via leptin receptor long and short forms about the amount of fat stored in the body. In this way leptin exerts a plethora of regulatory functions especially related to energy intake and metabolism, one of which is controlling the activity of the hypothalamo-pituitary-adrenal (HPA) stress axis. First, this review deals with the basic properties of leptin's structure and signaling at the organ, cell and molecule level, from lower vertebrates to humans but with emphasis on rodents because these have been investigated in most detail. Then, attention is given to the various interactions of adipose leptin with the HPA-axis, at the levels of the hypothalamus (especially the paraventricular nucleus), the anterior lobe of the pituitary gland (action on corticotropes) and the adrenal gland, where it releases corticosteroids needed for adequate stress adaptation. Also, possible local production and autocrine and paracrine actions of leptin at the hypothalamic and pituitary levels of the HPA-axis are being considered. Finally, a schematic model is presented showing the ways peripherally and centrally produced leptin may modulate, via the HPA-axis, stress adaptation in conjunction with the control of energy homeostasis.

Original languageEnglish (US)
Pages (from-to)28-36
Number of pages9
JournalGeneral and Comparative Endocrinology
Volume177
Issue number1
DOIs
StatePublished - May 15 2012
Externally publishedYes

Fingerprint

Leptin
leptin
Anterior Pituitary Gland
paraventricular hypothalamic nucleus
Leptin Receptors
White Adipose Tissue
white adipose tissue
Paraventricular Hypothalamic Nucleus
pituitary gland
adrenal glands
adrenal cortex hormones
Adrenal Glands
Energy Intake
energy metabolism
Energy Metabolism
Hypothalamus
Vertebrates
Rodentia
homeostasis
energy intake

Keywords

  • Adipose tissue
  • Adrenal gland
  • Arcuate nucleus
  • Corticosteroids
  • Corticotrope cells
  • Corticotropin-releasing factor
  • Energy metabolism
  • Leptin receptors
  • Paraventricular nucleus
  • Stress adaptation
  • Urocortin-1

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

Cite this

Leptin and the hypothalamo-pituitary-adrenal stress axis. / Roubos, Eric W.; Dahmen, Maurice; Kozicz, Tamas; Xu, Lu.

In: General and Comparative Endocrinology, Vol. 177, No. 1, 15.05.2012, p. 28-36.

Research output: Contribution to journalReview article

Roubos, Eric W. ; Dahmen, Maurice ; Kozicz, Tamas ; Xu, Lu. / Leptin and the hypothalamo-pituitary-adrenal stress axis. In: General and Comparative Endocrinology. 2012 ; Vol. 177, No. 1. pp. 28-36.
@article{2531b590f6b3419f94ab4a5a80a0147a,
title = "Leptin and the hypothalamo-pituitary-adrenal stress axis",
abstract = "Leptin is a 16-kDa protein mainly produced and secreted by white adipose tissue and informing various brain centers via leptin receptor long and short forms about the amount of fat stored in the body. In this way leptin exerts a plethora of regulatory functions especially related to energy intake and metabolism, one of which is controlling the activity of the hypothalamo-pituitary-adrenal (HPA) stress axis. First, this review deals with the basic properties of leptin's structure and signaling at the organ, cell and molecule level, from lower vertebrates to humans but with emphasis on rodents because these have been investigated in most detail. Then, attention is given to the various interactions of adipose leptin with the HPA-axis, at the levels of the hypothalamus (especially the paraventricular nucleus), the anterior lobe of the pituitary gland (action on corticotropes) and the adrenal gland, where it releases corticosteroids needed for adequate stress adaptation. Also, possible local production and autocrine and paracrine actions of leptin at the hypothalamic and pituitary levels of the HPA-axis are being considered. Finally, a schematic model is presented showing the ways peripherally and centrally produced leptin may modulate, via the HPA-axis, stress adaptation in conjunction with the control of energy homeostasis.",
keywords = "Adipose tissue, Adrenal gland, Arcuate nucleus, Corticosteroids, Corticotrope cells, Corticotropin-releasing factor, Energy metabolism, Leptin receptors, Paraventricular nucleus, Stress adaptation, Urocortin-1",
author = "Roubos, {Eric W.} and Maurice Dahmen and Tamas Kozicz and Lu Xu",
year = "2012",
month = "5",
day = "15",
doi = "10.1016/j.ygcen.2012.01.009",
language = "English (US)",
volume = "177",
pages = "28--36",
journal = "General and Comparative Endocrinology",
issn = "0016-6480",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Leptin and the hypothalamo-pituitary-adrenal stress axis

AU - Roubos, Eric W.

AU - Dahmen, Maurice

AU - Kozicz, Tamas

AU - Xu, Lu

PY - 2012/5/15

Y1 - 2012/5/15

N2 - Leptin is a 16-kDa protein mainly produced and secreted by white adipose tissue and informing various brain centers via leptin receptor long and short forms about the amount of fat stored in the body. In this way leptin exerts a plethora of regulatory functions especially related to energy intake and metabolism, one of which is controlling the activity of the hypothalamo-pituitary-adrenal (HPA) stress axis. First, this review deals with the basic properties of leptin's structure and signaling at the organ, cell and molecule level, from lower vertebrates to humans but with emphasis on rodents because these have been investigated in most detail. Then, attention is given to the various interactions of adipose leptin with the HPA-axis, at the levels of the hypothalamus (especially the paraventricular nucleus), the anterior lobe of the pituitary gland (action on corticotropes) and the adrenal gland, where it releases corticosteroids needed for adequate stress adaptation. Also, possible local production and autocrine and paracrine actions of leptin at the hypothalamic and pituitary levels of the HPA-axis are being considered. Finally, a schematic model is presented showing the ways peripherally and centrally produced leptin may modulate, via the HPA-axis, stress adaptation in conjunction with the control of energy homeostasis.

AB - Leptin is a 16-kDa protein mainly produced and secreted by white adipose tissue and informing various brain centers via leptin receptor long and short forms about the amount of fat stored in the body. In this way leptin exerts a plethora of regulatory functions especially related to energy intake and metabolism, one of which is controlling the activity of the hypothalamo-pituitary-adrenal (HPA) stress axis. First, this review deals with the basic properties of leptin's structure and signaling at the organ, cell and molecule level, from lower vertebrates to humans but with emphasis on rodents because these have been investigated in most detail. Then, attention is given to the various interactions of adipose leptin with the HPA-axis, at the levels of the hypothalamus (especially the paraventricular nucleus), the anterior lobe of the pituitary gland (action on corticotropes) and the adrenal gland, where it releases corticosteroids needed for adequate stress adaptation. Also, possible local production and autocrine and paracrine actions of leptin at the hypothalamic and pituitary levels of the HPA-axis are being considered. Finally, a schematic model is presented showing the ways peripherally and centrally produced leptin may modulate, via the HPA-axis, stress adaptation in conjunction with the control of energy homeostasis.

KW - Adipose tissue

KW - Adrenal gland

KW - Arcuate nucleus

KW - Corticosteroids

KW - Corticotrope cells

KW - Corticotropin-releasing factor

KW - Energy metabolism

KW - Leptin receptors

KW - Paraventricular nucleus

KW - Stress adaptation

KW - Urocortin-1

UR - http://www.scopus.com/inward/record.url?scp=84862817325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862817325&partnerID=8YFLogxK

U2 - 10.1016/j.ygcen.2012.01.009

DO - 10.1016/j.ygcen.2012.01.009

M3 - Review article

VL - 177

SP - 28

EP - 36

JO - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

SN - 0016-6480

IS - 1

ER -