Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals

Inna G. Ovsyannikova, Sarah J. White, Beth R. Larrabee, Diane E. Grill, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity. Leptin, an adipocyte-derived hormone/cytokine, has many immune regulatory functions and therefore could explain susceptibility to infections and poor vaccine outcomes. We recruited 159 healthy adults (50-74 years old) who were immunized with inactivated TIV influenza vaccine that contained A/California/7/2009/H1N1 virus. We found a strong correlation between leptin concentration and BMI (r=0.55, p<. 0.0001), but no association with hemagglutination antibody inhibition (HAI), B-cell, or granzyme B responses. We found a slight correlation between leptin concentration and an immunosenescence marker (TREC: T-cell receptor excision circles) level (r=0.23, p=0.01). We found eight SNPs in the LEP/LEPR/GHRL genes that were associated with leptin levels and four SNPs in the PTPN1/LEPR/STAT3 genes associated with peripheral blood TREC levels (p<. 0.05). Heterozygosity of the synonymous variant rs2230604 in the PTPN1 gene was associated with a significantly lower (531 vs. 259, p=0.005) TREC level, as compared to the homozygous major variant. We also found eight SNPs in the LEP/PPARG/CRP genes associated with variations in influenza-specific HAI and B-cell responses (p<. 0.05). Our results suggest that specific allelic variations in the leptin-related genes may influence adaptive immune responses to influenza vaccine.

Original languageEnglish (US)
Pages (from-to)881-887
Number of pages7
JournalVaccine
Volume32
Issue number7
DOIs
StatePublished - Feb 7 2014

Keywords

  • A/H1N1 virus
  • Adipocyte
  • BMI
  • Immune response
  • Immunosenescence
  • Influenza vaccine
  • Leptin
  • Obese
  • SNPs

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Ovsyannikova, I. G., White, S. J., Larrabee, B. R., Grill, D. E., Jacobson, R. M., & Poland, G. A. (2014). Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. Vaccine, 32(7), 881-887. https://doi.org/10.1016/j.vaccine.2013.12.009