Lepromatous leprosy masquerading as acute sarcoidosis: a case report and literature review.

Mrinal M Patnaik, Dale Hammerschmidt, Jo Anne H van Burik, Jose Jessurun, Peter Smyth

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Leprosy is uncommon in North America. Because it has a prolonged incubation period and can masquerade with a variety of manifestations, many patients with leprosy experience a significant delay in diagnosis and treatment. Lepra reactions are of 2 types: reversal (type 1) and erythema nodosum leprosum (ENL) (type 2). Type 1 or reversal reactions represent an increase in cell-mediated immunity, whereas type 2 or ENL is caused by antigen-antibody complex formation and deposition after antigen release from dying lepra bacilli. This article describes the diagnostic challenges presented by a Minnesota patient eventually found to have lepromatous leprosy. That challenge was compounded by the fact that the clinical scenario closely mimicked connective tissue/immune complex disease and by the fact that the patient presented in a location where the incidence and prevalence of leprosy is extremely low.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalMinnesota medicine.
Volume91
Issue number11
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Lepromatous Leprosy
Leprosy
Sarcoidosis
Erythema Nodosum
Immune Complex Diseases
North America
Antigen-Antibody Complex
Cellular Immunity
Connective Tissue
Bacillus
Antibody Formation
Antigens
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patnaik, M. M., Hammerschmidt, D., van Burik, J. A. H., Jessurun, J., & Smyth, P. (2008). Lepromatous leprosy masquerading as acute sarcoidosis: a case report and literature review. Minnesota medicine., 91(11), 30-33.

Lepromatous leprosy masquerading as acute sarcoidosis : a case report and literature review. / Patnaik, Mrinal M; Hammerschmidt, Dale; van Burik, Jo Anne H; Jessurun, Jose; Smyth, Peter.

In: Minnesota medicine., Vol. 91, No. 11, 11.2008, p. 30-33.

Research output: Contribution to journalReview article

Patnaik, MM, Hammerschmidt, D, van Burik, JAH, Jessurun, J & Smyth, P 2008, 'Lepromatous leprosy masquerading as acute sarcoidosis: a case report and literature review.', Minnesota medicine., vol. 91, no. 11, pp. 30-33.
Patnaik, Mrinal M ; Hammerschmidt, Dale ; van Burik, Jo Anne H ; Jessurun, Jose ; Smyth, Peter. / Lepromatous leprosy masquerading as acute sarcoidosis : a case report and literature review. In: Minnesota medicine. 2008 ; Vol. 91, No. 11. pp. 30-33.
@article{7ef7d45330984f3da63ea70053954b6e,
title = "Lepromatous leprosy masquerading as acute sarcoidosis: a case report and literature review.",
abstract = "Leprosy is uncommon in North America. Because it has a prolonged incubation period and can masquerade with a variety of manifestations, many patients with leprosy experience a significant delay in diagnosis and treatment. Lepra reactions are of 2 types: reversal (type 1) and erythema nodosum leprosum (ENL) (type 2). Type 1 or reversal reactions represent an increase in cell-mediated immunity, whereas type 2 or ENL is caused by antigen-antibody complex formation and deposition after antigen release from dying lepra bacilli. This article describes the diagnostic challenges presented by a Minnesota patient eventually found to have lepromatous leprosy. That challenge was compounded by the fact that the clinical scenario closely mimicked connective tissue/immune complex disease and by the fact that the patient presented in a location where the incidence and prevalence of leprosy is extremely low.",
author = "Patnaik, {Mrinal M} and Dale Hammerschmidt and {van Burik}, {Jo Anne H} and Jose Jessurun and Peter Smyth",
year = "2008",
month = "11",
language = "English (US)",
volume = "91",
pages = "30--33",
journal = "Minnesota medicine.",
issn = "0026-556X",
publisher = "Minnesota Medical Association",
number = "11",

}

TY - JOUR

T1 - Lepromatous leprosy masquerading as acute sarcoidosis

T2 - a case report and literature review.

AU - Patnaik, Mrinal M

AU - Hammerschmidt, Dale

AU - van Burik, Jo Anne H

AU - Jessurun, Jose

AU - Smyth, Peter

PY - 2008/11

Y1 - 2008/11

N2 - Leprosy is uncommon in North America. Because it has a prolonged incubation period and can masquerade with a variety of manifestations, many patients with leprosy experience a significant delay in diagnosis and treatment. Lepra reactions are of 2 types: reversal (type 1) and erythema nodosum leprosum (ENL) (type 2). Type 1 or reversal reactions represent an increase in cell-mediated immunity, whereas type 2 or ENL is caused by antigen-antibody complex formation and deposition after antigen release from dying lepra bacilli. This article describes the diagnostic challenges presented by a Minnesota patient eventually found to have lepromatous leprosy. That challenge was compounded by the fact that the clinical scenario closely mimicked connective tissue/immune complex disease and by the fact that the patient presented in a location where the incidence and prevalence of leprosy is extremely low.

AB - Leprosy is uncommon in North America. Because it has a prolonged incubation period and can masquerade with a variety of manifestations, many patients with leprosy experience a significant delay in diagnosis and treatment. Lepra reactions are of 2 types: reversal (type 1) and erythema nodosum leprosum (ENL) (type 2). Type 1 or reversal reactions represent an increase in cell-mediated immunity, whereas type 2 or ENL is caused by antigen-antibody complex formation and deposition after antigen release from dying lepra bacilli. This article describes the diagnostic challenges presented by a Minnesota patient eventually found to have lepromatous leprosy. That challenge was compounded by the fact that the clinical scenario closely mimicked connective tissue/immune complex disease and by the fact that the patient presented in a location where the incidence and prevalence of leprosy is extremely low.

UR - http://www.scopus.com/inward/record.url?scp=59049094900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59049094900&partnerID=8YFLogxK

M3 - Review article

C2 - 19108542

AN - SCOPUS:59049094900

VL - 91

SP - 30

EP - 33

JO - Minnesota medicine.

JF - Minnesota medicine.

SN - 0026-556X

IS - 11

ER -