We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.
|Original language||English (US)|
|Title of host publication||Gene Therapy and Gene Delivery Systems|
|Number of pages||23|
|State||Published - Nov 8 2005|
|Name||Advances in Biochemical Engineering/Biotechnology|
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology