Lentiviral vectors

Nils Loewen, Eric M. Poeschla

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Scopus citations

Abstract

We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

Original languageEnglish (US)
Title of host publicationGene Therapy and Gene Delivery Systems
Pages169-191
Number of pages23
DOIs
StatePublished - Nov 8 2005

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume99
ISSN (Print)0724-6145

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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  • Cite this

    Loewen, N., & Poeschla, E. M. (2005). Lentiviral vectors. In Gene Therapy and Gene Delivery Systems (pp. 169-191). (Advances in Biochemical Engineering/Biotechnology; Vol. 99). https://doi.org/10.1007/10_007